Functions of MDMX in the modulation of the p53-response.
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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerizationAn observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomasTumorigenesis promotes Mdm4-S overexpression.microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network.ROS and p53 in regulation of UVB-induced HDM2 alternative splicingStress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct waysAntisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth.Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machineryMDMX contains an autoinhibitory sequence element.Calpain-mediated degradation of MDMx/MDM4 contributes to HIV-induced neuronal damage.The Zn-finger domain of MdmX suppresses cancer progression by promoting genome stability in p53-mutant cells.Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53.MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.Multidimensional control of cell structural robustness.EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis.MDM4 is a rational target for treating breast cancers with mutant p53.MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.Targeting MDM4 Splicing in Cancers.p53 is activated in response to disruption of the pre-mRNA splicing machinery.Mice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity.In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas.
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Functions of MDMX in the modulation of the p53-response.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 March 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Functions of MDMX in the modulation of the p53-response.
@en
Functions of MDMX in the modulation of the p53-response.
@nl
type
label
Functions of MDMX in the modulation of the p53-response.
@en
Functions of MDMX in the modulation of the p53-response.
@nl
prefLabel
Functions of MDMX in the modulation of the p53-response.
@en
Functions of MDMX in the modulation of the p53-response.
@nl
P2860
P921
P356
P1476
Functions of MDMX in the modulation of the p53-response.
@en
P2093
Aart G Jochemsen
Kristiaan Lenos
P2860
P304
P356
10.1155/2011/876173
P577
2011-03-22T00:00:00Z