Divergence and convergence in enzyme evolution: parallel evolution of paraoxonases from quorum-quenching lactonases
about
Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.Structural and Enzymatic characterization of the lactonase SisLac from Sulfolobus islandicusCharacterisation of the organophosphate hydrolase catalytic activity of SsoPoxHydrogen atoms in protein structures: high-resolution X-ray diffraction structure of the DFPaseDifferential active site loop conformations mediate promiscuous activities in the lactonase SsoPoxStructural and Enzymatic Characterization of the Phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenesSwitching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263TrpAn Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based CofactorsAIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAsCrystallization and preliminary X-ray diffraction analysis of the lactonaseVmoLac fromVulcanisaeta moutnovskiaComputational protein engineering: bridging the gap between rational design and laboratory evolution.Genomics-guided analysis of NAD recycling yields functional elucidation of COG1058 as a new family of pyrophosphatases.Genomics of Parallel Experimental Evolution in DrosophilaBiochemical characterization of a dihydroneopterin aldolase used for methanopterin biosynthesis in methanogens.Divergence and convergence in enzyme evolution.The evolution of enzyme function in the isomerases.Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron.SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase.Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution.Site-directed mutagenesis maps interactions that enhance cognate and limit promiscuous catalysis by an alkaline phosphatase superfamily phosphodiesterase.Toward a systems biology perspective on enzyme evolution.Promiscuity in the Enzymatic Catalysis of Phosphate and Sulfate Transfer.Probing the mechanisms for the selectivity and promiscuity of methyl parathion hydrolase.Conformational diversity analysis reveals three functional mechanisms in proteins.Paraoxonase 1 - an Update of the Antioxidant Properties of High- Density LipoproteinsStructural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase with Atypical SelectivityAre there acyl-homoserine lactones within mammalian intestines?High chlorpyrifos resistance in Culex pipiens mosquitoes: strong synergy between resistance genesActive Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1.Quorum quenching: role in nature and applied developments.The quorum-quenching lactonase from Geobacillus caldoxylosilyticus: purification, characterization, crystallization and crystallographic analysis.Phenotypic and genotypic convergences are influenced by historical contingency and environment in yeast.Modeling catalytic promiscuity in the alkaline phosphatase superfamily.Crystallization and preliminary X-ray diffraction analysis of the organophosphorus hydrolase OPHC2 from Pseudomonas pseudoalcaligenesCrystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia.The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases (PONs) relate to bacterial homoserine lactonases.Multiple mechanisms contribute to lateral transfer of an organophosphate degradation (opd) island in Sphingobium fuliginis ATCC 27551.Novel reporter for identification of interference with acyl homoserine lactone and autoinducer-2 quorum sensing.Paraoxonase 1 lactonase activity and distribution in the HDL subclasses in the cord blood.Similar Active Sites and Mechanisms Do Not Lead to Cross-Promiscuity in Organophosphate Hydrolysis: Implications for Biotherapeutic Engineering.
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P2860
Divergence and convergence in enzyme evolution: parallel evolution of paraoxonases from quorum-quenching lactonases
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
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2011年學術文章
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name
Divergence and convergence in ...... om quorum-quenching lactonases
@en
Divergence and convergence in ...... m quorum-quenching lactonases.
@nl
type
label
Divergence and convergence in ...... om quorum-quenching lactonases
@en
Divergence and convergence in ...... m quorum-quenching lactonases.
@nl
prefLabel
Divergence and convergence in ...... om quorum-quenching lactonases
@en
Divergence and convergence in ...... m quorum-quenching lactonases.
@nl
P2860
P356
P1476
Divergence and convergence in ...... om quorum-quenching lactonases
@en
P2093
Dan S Tawfik
P2860
P356
10.1074/JBC.R111.257329
P407
P50
P577
2011-11-08T00:00:00Z