The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases (PONs) relate to bacterial homoserine lactonases.
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Substrate Deconstruction and the Nonadditivity of Enzyme RecognitionSwitching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263TrpMutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history.Paraoxonase 2 serves a proapopotic function in mouse and human cells in response to the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-homoserine lactone.Assessing the prediction fidelity of ancestral reconstruction by a library approach.An Engineered Version of Human PON2 Opens the Way to Understand the Role of Its Post-Translational Modifications in Modulating Catalytic Activity.Structural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase with Atypical SelectivityN-(3-oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins.Communication between Bacteria and Their Hosts.Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1.Paraoxonase 1 in neurological disorders.Dynamics and constraints of enzyme evolution.Homocysteine, Paraoxonase-1 and Vascular Endothelial Dysfunction: Omnibus viis Romam Pervenitur.Quorum quenching: role in nature and applied developments.Current and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes.Quorum Signal Inhibitors and Their Potential Use against Fish Diseases.Identification and analysis of the salt tolerant property of AHL lactonase (AiiATSAWB ) of Bacillus species.The quorum-quenching lactonase from Geobacillus caldoxylosilyticus: purification, characterization, crystallization and crystallographic analysis.The Organophosphate Degradation (opd) Island-borne Esterase-induced Metabolic Diversion in Escherichia coli and Its Influence on p-Nitrophenol Degradation.Ambiguous evidence for assigning DddQ as a dimethylsulfoniopropionate lyase and oceanic dimethylsulfide producerParaoxonase 1 lactonase activity and distribution in the HDL subclasses in the cord blood.Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme.Lowered PON1 activities are strongly associated with depression and bipolar disorder, recurrence of (hypo)mania and depression, increased disability and lowered quality of life.Multiplicity of Quorum Quenching Enzymes: A Potential Mechanism to Limit Quorum Sensing Bacterial Population.Towards Understanding the Catalytic Mechanism of Human Paraoxonase 1: Experimental and In Silico Mutagenesis Studies.On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins.
P2860
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P2860
The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases (PONs) relate to bacterial homoserine lactonases.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The evolutionary origins of de ...... cterial homoserine lactonases.
@en
The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases
@nl
type
label
The evolutionary origins of de ...... cterial homoserine lactonases.
@en
The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases
@nl
prefLabel
The evolutionary origins of de ...... cterial homoserine lactonases.
@en
The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases
@nl
P2093
P2860
P356
P1476
The evolutionary origins of de ...... cterial homoserine lactonases.
@en
P2093
Adrian Hugenmatter
Dan S Tawfik
Hagit Bar-Rogovsky
P2860
P304
23914-23927
P356
10.1074/JBC.M112.427922
P407
P577
2013-06-20T00:00:00Z