Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.
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Neurodegeneration and microtubule dynamics: death by a thousand cutsMicrotubule-stabilizing agents as potential therapeutics for neurodegenerative diseaseAxonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injuryTau Biology and Tau-Directed Therapies for Alzheimer's DiseaseProtein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusAβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone DGlial contributions to neurodegeneration in tauopathies.Mechanisms responsible for the inhibitory effects of epothilone B on scar formation after spinal cord injuryBrain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.A previously undescribed tubulin binderProtein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5/p25 kinase complexRescue of tau-induced synaptic transmission pathology by paclitaxel.Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site.Tools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease.CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon ElongationTau stabilizes microtubules by binding at the interface between tubulin heterodimers.The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease.Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related TauopathiesEnd-binding proteins sensitize microtubules to the action of microtubule-targeting agents.Direct modulation of microtubule stability contributes to anthracene general anesthesia.Beyond taxol: microtubule-based treatment of disease and injury of the nervous system.Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons.Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer's disease.Back to the tubule: microtubule dynamics in Parkinson's disease.Genetic strategies to investigate neuronal circuit properties using stem cell-derived neurons.Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration.Protein aggregate formation in oligodendrocytes: tau and the cytoskeleton at the intersection of neuroprotection and neurodegeneration.Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesisPeloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease.Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal.Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine.Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment.Phenolic Compounds Isolated from Caesalpinia coriaria Induce S and G2/M Phase Cell Cycle Arrest Differentially and Trigger Cell Death by Interfering with Microtubule Dynamics in Cancer Cell Lines.Interactome Analysis of Microtubule-targeting Agents Reveals Cytotoxicity Bases in Normal Cells.Microtubule organization, dynamics and functions in differentiated cells.In vitro study on the alterations of brain tubulin structure and assembly affected by magnetite nanoparticles.
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Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Microtubule stabilizing agents ...... neurodegenerative tauopathies.
@en
type
label
Microtubule stabilizing agents ...... neurodegenerative tauopathies.
@en
prefLabel
Microtubule stabilizing agents ...... neurodegenerative tauopathies.
@en
P2093
P2860
P50
P356
P1476
Microtubule stabilizing agents ...... neurodegenerative tauopathies.
@en
P2093
Amos B Smith
Kurt R Brunden
Virginia M-Y Lee
P2860
P304
P356
10.1021/JM301079Z
P407
P577
2012-09-28T00:00:00Z