Targeting class I histone deacetylases in cancer therapy.
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SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanismsNew and emerging HDAC inhibitors for cancer treatmentDevelopment of chidamide for peripheral T-cell lymphoma, the first orphan drug approved in ChinaThe therapeutic potential of class I selective histone deacetylase inhibitors in ovarian cancerRNAi screening identifies HAT1 as a potential drug target in esophageal squamous cell carcinoma.Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2.Maspin expression in prostate tumor elicits host anti-tumor immunityIdentification of an intrinsic determinant critical for maspin subcellular localization and function.Potential anti-cancer effect of N-hydroxy-7-(2-naphthylthio) heptanomide (HNHA), a novel histone deacetylase inhibitor, for the treatment of thyroid cancer.High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility.The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer.The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases.Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next.Epigenetic regulation of RGS2 (Regulator of G-protein signaling 2) in chemoresistant ovarian cancer cells.Epigenetic-mediated immune suppression of positive co-stimulatory molecules in chemoresistant ovarian cancer cells.HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways.Synthesis, Biological Evaluation, and Computer-Aided Drug Designing of New Derivatives of Hyperactive Suberoylanilide Hydroxamic Acid Histone Deacetylase Inhibitors.Honokiol induces cell cycle arrest and apoptosis via inhibiting class I histone deacetylases in acute myeloid leukemia.Epigenetic targets in hepatocellular carcinoma cells: identification of chaperone protein complexes with histone deacetylases.HDAC8 Prevents Anthrax Lethal Toxin-induced Cell Cycle Arrest through Silencing PTEN in Human Monocytic THP-1 Cells.HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity.Transcription-dependent association of HDAC2 with active chromatin.
P2860
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P2860
Targeting class I histone deacetylases in cancer therapy.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artículo científico
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name
Targeting class I histone deacetylases in cancer therapy.
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type
label
Targeting class I histone deacetylases in cancer therapy.
@en
prefLabel
Targeting class I histone deacetylases in cancer therapy.
@en
P2093
P2860
P1476
Targeting class I histone deacetylases in cancer therapy.
@en
P2093
Dilshad H Khan
Geneviève P Delcuve
James R Davie
P2860
P356
10.1517/14728222.2013.729042
P407
P577
2012-10-15T00:00:00Z