Is exposure to cyanobacteria an environmental risk factor for amyotrophic lateral sclerosis and other neurodegenerative diseases?
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The non-protein amino acid BMAA is misincorporated into human proteins in place of L-serine causing protein misfolding and aggregationMaternal transfer of the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) via milk to suckling offspringDietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brainALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the diseaseSearching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programmeMapping amyotrophic lateral sclerosis lake risk factors across northern New EnglandMarine harmful algal blooms, human health and wellbeing: challenges and opportunities in the 21st centuryAnalysis of β-N-methylamino-L-alanine (BMAA) in spirulina-containing supplements by liquid chromatography-tandem mass spectrometry.Exome sequencing of case-unaffected-parents trios reveals recessive and de novo genetic variants in sporadic ALS.Selective quantitation of the neurotoxin BMAA by use of hydrophilic-interaction liquid chromatography-differential mobility spectrometry-tandem mass spectrometry (HILIC-DMS-MS/MS).Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009-2011.A Multiscale Mapping Assessment of Lake Champlain Cyanobacterial Harmful Algal BloomsExposure to environmental toxicants and pathogenesis of amyotrophic lateral sclerosis: state of the art and research perspectives.MicroRNAs as potential circulating biomarkers for amyotrophic lateral sclerosis.A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans.Use of three monitoring approaches to manage a major Chrysosporum ovalisporum bloom in the Murray River, Australia, 2016.Motoneuron Disease: Basic Science.No evidence of association between polymorphisms in four genes and sporadic amyotrophic lateral sclerosis in Han Chinese.Seafood sold in Sweden contains BMAA: A study of free and total concentrations with UHPLC-MS/MS and dansyl chloride derivatization.Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.The natural non-protein amino acid N-β-methylamino-L-alanine (BMAA) is incorporated into protein during synthesis.An evaluation of a handheld spectroradiometer for the near real-time measurement of cyanobacteria for bloom management purposes.Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients.Mechanisms of L-Serine Neuroprotection in vitro Include ER Proteostasis Regulation.ALS-Related Mutant FUS Protein Is Mislocalized to Cytoplasm and Is Recruited into Stress Granules of Fibroblasts from Asymptomatic FUS P525L Mutation Carriers.Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-L-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring-Potential Involvement of DNA Damage and Oxidative Stress.Repeated five-day administration of L-BMAA, microcystin-LR, or as mixture, in adult C57BL/6 mice - lack of adverse cognitive effects.Assessing the Combined Toxicity of BMAA and Its Isomers 2,4-DAB and AEG In Vitro Using Human Neuroblastoma Cells.Phase I clinical trial of safety of L-serine for ALS patients.BMAA and Neurodegenerative Illness.Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis.Algal Bloom Expansion Increases Cyanotoxin Risk in Food.Global expansion of toxic and non-toxic cyanobacteria: effect on ecosystem functioningAmyotrophic lateral sclerosisIdentifying aerosolized cyanobacteria in the human respiratory tract: A proposed mechanism for cyanotoxin-associated diseasesTheme 8 Epidemiology
P2860
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P2860
Is exposure to cyanobacteria an environmental risk factor for amyotrophic lateral sclerosis and other neurodegenerative diseases?
description
article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Is exposure to cyanobacteria a ...... er neurodegenerative diseases?
@en
type
label
Is exposure to cyanobacteria a ...... er neurodegenerative diseases?
@en
prefLabel
Is exposure to cyanobacteria a ...... er neurodegenerative diseases?
@en
P2093
P2860
P921
P1476
Is exposure to cyanobacteria a ...... er neurodegenerative diseases?
@en
P2093
Amy R Borenstein
Barry H Rosen
Elijah W Stommel
Geoffrey A Codd
Lorene M Nelson
Walter G Bradley
P2860
P304
P356
10.3109/21678421.2012.750364
P50
P577
2013-01-04T00:00:00Z