Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction - Test2 - elhamkhani - TriplyDB

Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction

Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction

http://www.wikidata.org/entity/Q38110992

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How do cilia organize signalling cascades?Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion Measuring the primary cilium length: improved method for unbiased high-throughput analysis.PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity The Hedgehog signalling pathway in bone formation Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation The role of GLI1 for 5-Fu resistance in colorectal cancer GLI1-mediated regulation of side population is responsible for drug resistance in gastric cancer Diverse cell type-specific mechanisms localize G protein-coupled receptors to Caenorhabditis elegans sensory cilia Neural crest cell signaling pathways critical to cranial bone development and pathology.CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.Ciliary Entry of the Hedgehog Transcriptional Activator Gli2 Is Mediated by the Nuclear Import Machinery but Differs from Nuclear Transport in Being Imp-α/β1-Independent Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome.Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation.The G protein Gαs acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis.Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome.Gated entry into the ciliary compartment.Molecular connections between nuclear and ciliary import processes.Role for the IFT-A Complex in Selective Transport to the Primary Cilium.Suppressor of Fused Chaperones Gli Proteins To Generate Transcriptional Responses to Sonic Hedgehog Signaling.Cilia and coordination of signaling networks during heart development.Sperm protein 17 is an oncofetal antigen: a lesson from a murine model.Developmental signaling: does it bridge the gap between cilia dysfunction and renal cystogenesis?Communication, the centrosome and the immunological synapse.Sonic hedgehog signaling in Basal cell nevus syndrome.Signal transduction: From the atomic age to the post-genomic era Bardet-Biedl syndrome: Is it only cilia dysfunction?Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice.Concise Review: Primary Cilia: Control Centers for Stem Cell Lineage Specification and Potential Targets for Cell-Based Therapies.Bardet-Biedl syndrome 3 regulates the development of cranial base midline structures Rab23 activities and human cancer-emerging connections and mechanisms.Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy.Functional Study of the Primary Cilia in ADPKD.

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Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction

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J.GDE.2013.04.008

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Current Opinion in Genetics & Development

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Chuwen Lin

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Pao-Tien Chuang

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Yoko Inès Nozawa

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P2860

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus

Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes

BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

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10.1016/J.GDE.2013.04.008

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