C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1
about
C/EBPα Dysregulation in AML and ALLTranscriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesReintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiationMicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNSThe role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECsCell-type-specific activation and repression of PU.1 by a complex of discrete, functionally specialized cis-regulatory elementsRegulation of HIV-1 transcription in cells of the monocyte-macrophage lineage.LPS independent activation of the pro-inflammatory receptor Trem1 by C/EBPε in granulocytesInferring transcription factor complexes from ChIP-seq data.Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AMLThe multifaceted functions of C/EBPα in normal and malignant haematopoiesis.MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cellsGranulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells.SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesisAP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcriptionC/EBPα, C/EBPα oncoproteins, or C/EBPβ preferentially bind NF-κB p50 compared with p65, focusing therapeutic targeting on the C/EBP:p50 interaction.IL-32θ inhibits monocytic differentiation of leukemia cells by attenuating expression of transcription factor PU.1.ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis.In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.The role of bioactive nanofibers in enamel regeneration mediated through integrin signals acting upon C/EBPα and c-Jun.NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production.Identification of neuronal target genes for CCAAT/enhancer binding proteins.Combinatorial recruitment of CREB, C/EBPβ and c-Jun determines activation of promoters upon keratinocyte differentiationM-CSF elevates c-Fos and phospho-C/EBPalpha(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification.MAPK signaling pathways in the regulation of hematopoiesis.The versatility of haematopoietic stem cells: implications for leukaemia.The role of transcription factors in the guidance of granulopoiesis.Transcription of inflammatory genes: long noncoding RNA and beyondATXN8 -62 G/A promoter polymorphism and risk of Taiwanese Parkinson's disease.C/EBPα in normal and malignant myelopoiesis.Characterization of the promoter region of TCblR/CD320 gene, the receptor for cellular uptake of transcobalamin-bound cobalamin.C/EBPα represses slow myosin heavy chain 2 gene expression in developing avian myotubes.The transcription factor PU.1 is critical for viability and function of human brain microglia.Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells.Nuclear ERK5 inhibits progression of leukemic monocytes to macrophages by regulating the transcription factor PU.1 and heat shock protein HSP70.ERK1/2 promoted proliferation and inhibited apoptosis of human cervical cancer cells and regulated the expression of c-Fos and c-Jun proteins.
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C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
C/EBP alpha:AP-1 leucine zippe ...... C/EBP alpha homodimers or AP-1
@en
type
label
C/EBP alpha:AP-1 leucine zippe ...... C/EBP alpha homodimers or AP-1
@en
prefLabel
C/EBP alpha:AP-1 leucine zippe ...... C/EBP alpha homodimers or AP-1
@en
P2093
P2860
P356
P1433
P1476
C/EBP alpha:AP-1 leucine zippe ...... C/EBP alpha homodimers or AP-1
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210940
P407
P577
2007-11-19T00:00:00Z
P5875
P6179
1045384733