about
Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genesIdentification and characterization of a family of mammalian methyl-CpG binding proteinsIdentification and characterization of the human XIST gene promoter: implications for models of X chromosome inactivationThe p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressorThe Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modulesMBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complexThe thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sitesMeCP2 in neurons: closing in on the causes of Rett syndromeA mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndromeThe NuRD component Mbd3 is required for pluripotency of embryonic stem cellsMbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cellsClosely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse developmentThe methyl-CpG binding proteins Mecp2, Mbd2 and Kaiso are dispensable for mouse embryogenesis, but play a redundant function in neural differentiation.NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression.Dynamic reprogramming of DNA methylation in the early mouse embryo.Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.Human diseases with underlying defects in chromatin structure and modification.MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line.Epigenetic reprogramming: how now, cloned cow?Methyl-CpG binding proteins and cancer: are MeCpGs more important than MBDs?The methyl-CpG binding domain and the evolving role of DNA methylation in animals.The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex.The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.Mbd2 contributes to DNA methylation-directed repression of the Xist gene.Sin3a is essential for the genome integrity and viability of pluripotent cellsConstraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification.NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development.Transcriptional repressors: multifaceted regulators of gene expression.CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy nowThe function of chromatin modifiers in lineage commitment and cell fate specification.3D structures of individual mammalian genomes studied by single-cell Hi-C.MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner.c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex.Gene silencing quantitatively controls the function of a developmental trans-activator.Kaiso-deficient mice show resistance to intestinal cancer.Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complexNuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fateA high-resolution map of transcriptional repression.Vestiges of a DNA methylation system in Drosophila melanogaster?
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Brian Hendrich
@ast
Brian Hendrich
@en
Brian Hendrich
@es
Brian Hendrich
@nl
Brian Hendrich
@sl
type
label
Brian Hendrich
@ast
Brian Hendrich
@en
Brian Hendrich
@es
Brian Hendrich
@nl
Brian Hendrich
@sl
prefLabel
Brian Hendrich
@ast
Brian Hendrich
@en
Brian Hendrich
@es
Brian Hendrich
@nl
Brian Hendrich
@sl
P106
P21
P31
P496
0000-0002-0231-3073