Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.
about
Enzymatic methods for glyco(diversification/randomization) of drugs and small moleculesMarine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural productsNatural-product sugar biosynthesis and enzymatic glycodiversification.Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization.High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity.Probing the aglycon promiscuity of an engineered glycosyltransferaseMass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton.Glycosyltransferases: mechanisms and applications in natural product development.Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489.The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme.Acyl transfer in clorobiocin biosynthesis: involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar.
P2860
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P2860
Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Initial characterization of no ...... of the antibiotic novobiocin.
@en
type
label
Initial characterization of no ...... of the antibiotic novobiocin.
@en
prefLabel
Initial characterization of no ...... of the antibiotic novobiocin.
@en
P2093
P921
P356
P1433
P1476
Initial characterization of no ...... s of the antibiotic novobiocin
@en
P2093
Christopher T Walsh
Daniel Kahne
John W Anderson
P304
P356
10.1021/BI0340088
P407
P577
2003-04-01T00:00:00Z