about
Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparumPharmacological activation of myosin II paralogs to correct cell mechanics defects.Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cellsPhysiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV.Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr).Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate SynthaseDXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines.Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate.Probing phosphorylation by non-mammalian isoprenoid biosynthetic enzymes using (1)H-(31)P-(31)P correlation NMR spectroscopy.Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.Versatile (1)H-(31)P-(31)P COSY 2D NMR techniques for the characterization of polyphosphorylated small molecules.IspG converts an epoxide substrate analogue to (E)-4-hydroxy-3-methylbut-2-enyl diphosphate: implications for IspG catalysis in isoprenoid biosynthesis.A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN.Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors.Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-d-xylo-4-hexulose 3-epimeraseNovel method for the immobilization of nucleotidesA novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidatesOxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteriaSynthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2- C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human PathogensTargeting the Unique Mechanism of Bacterial 1-Deoxy-d-xylulose-5-phosphate SynthaseEnamide Prodrugs of Acetyl Phosphonate Deoxy-d-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial AgentsActive Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate SynthaseToward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial MetabolismX-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Caren L Freel Meyers
@en
Caren L Freel Meyers
@nl
type
label
Caren L Freel Meyers
@en
Caren L Freel Meyers
@nl
prefLabel
Caren L Freel Meyers
@en
Caren L Freel Meyers
@nl
P106
P31
P496
0000-0003-1458-0897