Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.
about
The emerging role of histone lysine demethylases in prostate cancerLSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition.Mitochondria, cholesterol and cancer cell metabolismTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyEnvironmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer PreventionDesign of small molecule epigenetic modulatorsHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionNutrient sensing, metabolism, and cell growth controlAn Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji DemethylasesCell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activityEpigenetics in Cancer: A Hematological PerspectiveEZH2 in Bladder Cancer, a Promising Therapeutic TargetThe Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear StructureKDM1 class flavin-dependent protein lysine demethylasesExpanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatinHistone lysine demethylases in breast cancer.Rejuvenating sirtuins: the rise of a new family of cancer drug targetsSmall molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cellsDoxorubicin, DNA torsion, and chromatin dynamics.Epigenetic modifications by dietary phytochemicals: implications for personalized nutritionA developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster.Cancer genetics and epigenetics: two sides of the same coin?Targeting histone lysine demethylases - progress, challenges, and the futureExpression and significance of histone H3K27 demethylases in renal cell carcinoma.Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development.Development of substrate-selective probes for affinity pulldown of histone demethylases.Oncogenic features of PHF8 histone demethylase in esophageal squamous cell carcinoma.Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.Novel Scaffolds of Cell-Active Histone Demethylase Inhibitors Identified from High-Throughput Screening.Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM(+) AFP(+) hepatocellular carcinoma.Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.Epigenetic mechanisms in neurological diseaseSubsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine.Epigenetically mediated spontaneous reduction of NFAT1 expression causes imbalanced metabolic activities of articular chondrocytes in aged mice.Manipulating the epigenome for the treatment of urological malignancies.Understanding the language of Lys36 methylation at histone H3.LET-418/Mi2 and SPR-5/LSD1 cooperatively prevent somatic reprogramming of C. elegans germline stem cells.Biological activities of guanidine compounds, 2008 - 2012 update.
P2860
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P2860
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.
@en
type
label
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.
@en
prefLabel
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.
@en
P2860
P356
P1433
P1476
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.
@en
P2860
P304
P356
10.1177/1947601911417976
P577
2011-06-01T00:00:00Z