Rejuvenating sirtuins: the rise of a new family of cancer drug targets - Test2 - elhamkhani - TriplyDB

Rejuvenating sirtuins: the rise of a new family of cancer drug targets

Rejuvenating sirtuins: the rise of a new family of cancer drug targets

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Epigenetics in Brain Tumors: HDACs Take Center Stage Computer-aided Molecular Design of Compounds Targeting Histone Modifying Enzymes Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells New insights into the treatment of multiple myeloma with histone deacetylase inhibitors.Epigenetic drugs against cancer: an evolving landscape.Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.Selectivity hot-spots of sirtuin catalytic cores.Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model.Sirtuins, Cell Senescence, and Vascular Aging The emerging and diverse roles of sirtuins in cancer: a clinical perspective.SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation.Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer.Plant polyphenols in the treatment of age-associated diseases: revealing the pleiotropic effects of icariin by network analysis.Ionizing radiation-induced oxidative stress, epigenetic changes and genomic instability: the pivotal role of mitochondria.Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach.Exploring NAD+ metabolism in host-pathogen interactions.SIRT3 inhibits cell proliferation in human gastric cancer through down-regulation of Notch-1.Chromatin determinants impart camptothecin sensitivity.Nicotinic acid: A case for a vitamin that moonlights for cancer?Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer

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Rejuvenating sirtuins: the rise of a new family of cancer drug targets

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2013 nî lūn-bûn

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Rejuvenating sirtuins: the rise of a new family of cancer drug targets

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Current Pharmaceutical Design

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Rejuvenating sirtuins: the rise of a new family of cancer drug targets

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Alberto Ballestrero

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Alberto Del Rio

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Alessia Grozio

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Alessio Nencioni

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Inga Bauer

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Marco Daniele Parenti

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Creative Commons Attribution-NonCommercial 3.0 Unported

P2860

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

Negative control of p53 by Sir2alpha promotes cell survival under stress

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive

SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability

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614-623

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scholarly article

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10.2174/138161213804581954

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4

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19

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Santina Bruzzone

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2013-01-01T00:00:00Z

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