KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation.

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KSHV de-regulates host cellular replication during lytic reactivation by disrupting the MCM complex through ORF59

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Q57753235-1cccfd1c-420b-9627-9df4-6d027a568655

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KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation.

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KSHV encoded ORF59 modulates h ...... to promote viral reactivation.

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KSHV encoded ORF59 modulates h ...... to promote viral reactivation.

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KSHV encoded ORF59 modulates h ...... to promote viral reactivation.

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KSHV encoded ORF59 modulates h ...... to promote viral reactivation.

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Maria McDowell-Sargent

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Pravinkumar Purushothaman

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Roxanne C Strahan

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The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

Negative regulation of transcription by the type II arginine methyltransferase PRMT5

Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus

Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

Regulation of chromatin by histone modifications

Identification of direct transcriptional targets of the Kaposi's sarcoma-associated herpesvirus Rta lytic switch protein by conditional nuclear localization

The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen

Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity

The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

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e1006482

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scholarly article

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10.1371/JOURNAL.PPAT.1006482

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http://www.w3.org/2001/XMLSchema#string

P478

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Subhash Verma

Timsy Uppal

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2017-07-05T00:00:00Z

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28678843

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5513536

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KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation.

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P2860

P2860

KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation.

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P932