Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. - Test2 - elhamkhani - TriplyDB

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

http://www.wikidata.org/entity/Q38925490

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Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases Utility of Induced Pluripotent Stem Cells for the Study and Treatment of Genetic Diseases: Focus on Childhood Neurological Disorders Is Huntingtin Dispensable in the Adult Brain?Induced Pluripotent Stem Cells: Global Research Trends.Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.Pluripotent stem cells in disease modelling and drug discovery.A new era of disease modeling and drug discovery using induced pluripotent stem cells.Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells.Modeling simple repeat expansion diseases with iPSC technology.Induced Pluripotent Stem Cells in Huntington's Disease Research: Progress and Opportunity.Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy.Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.Optimization of trans-Splicing for Huntington's Disease RNA Therapy.Life and death rest on a bivalent chromatin state.Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.Huntington disease: Banking on ATM.Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes.Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.DNA REPAIR. Drugging DNA repair.A unifying mechanism in neurodegeneration

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Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

http://www.wikidata.org/entity/Q38925490

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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name

Targeting ATM ameliorates muta ...... odels of Huntington's disease.

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type

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Targeting ATM ameliorates muta ...... odels of Huntington's disease.

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Targeting ATM ameliorates muta ...... odels of Huntington's disease.

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SCITRANSLMED.3010523

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Science Translational Medicine

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Targeting ATM ameliorates muta ...... odels of Huntington's disease.

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Alex Osmand

http://www.w3.org/2001/XMLSchema#string

Clive N Svendsen

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David F Fischer

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Erin Greiner

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Ethan Signer

http://www.w3.org/2001/XMLSchema#string

Ignacio Munoz-Sanjuan

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Ismael Al-Ramahi

http://www.w3.org/2001/XMLSchema#string

Jingbo Xiao

http://www.w3.org/2001/XMLSchema#string

Juan Botas

http://www.w3.org/2001/XMLSchema#string

Juan J Marugan

http://www.w3.org/2001/XMLSchema#string

P2860

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

Cytoplasmic ATM in neurons modulates synaptic function

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration

High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model

The DNA Damage Response: Making It Safe to Play with Knives

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

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268ra178

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scholarly article

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10.1126/SCITRANSLMED.3010523

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268

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6

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Henry J. Waldvogel

Harry V Vinters

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2014-12-01T00:00:00Z

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269990817

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25540325

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Huntington disease