Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.
about
Design of small molecule epigenetic modulatorsLysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cellsUtilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens.Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilizationDiscovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stagesRational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors.AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosolDesign and Synthesis of Novel Anti-Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit.Acetylation of p53 Protein at Lysine 120 Up-regulates Apaf-1 Protein and Sensitizes the Mitochondrial Apoptotic Pathway.Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core.HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer.Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte functionClass I HDACs specifically regulate E-cadherin expression in human renal epithelial cells.Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next.Selective class IIa HDAC inhibitors: myth or reality.Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization.Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups.A seasonal switch in histone deacetylase gene expression in the hypothalamus and their capacity to modulate nuclear signaling pathways.HDACs and HDAC Inhibitors in Cancer Development and Therapy.HDAC5 promotes colorectal cancer cell proliferation by up-regulating DLL4 expressionSynthesis, antimalarial properties, and SAR studies of alkoxyurea-based HDAC inhibitors.Structure-activity relationships of hydroxamate-based histone deacetylase-8 inhibitors: reality behind anticancer drug discovery.HDAC2/3 binding and deacetylation of BubR1 initiates spindle assembly checkpoint silencing.Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment.STAT1‑HDAC4 signaling induces epithelial‑mesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2
P2860
Q26850027-0009B712-7919-4966-BAA4-5CE0EDE022E4Q33798591-5EE73C47-70F9-457B-8720-C4545086343EQ33834432-F9F94C58-7D8D-4BB8-8A7B-95DE72028E77Q34151939-618AE9A8-1FCC-4427-884C-A5D87789979CQ35059923-A1EB81FA-37A0-46B7-AFED-D144A6157AD0Q35182742-2CA3ACF9-8CE3-4FCB-925D-BF1501003E73Q35904431-DEE70C44-EC43-4B55-BD2F-87929EE75C65Q36186609-A6E1A493-3DC0-4E39-B34C-5023492E2C31Q36314088-6F1F13FE-7719-4AF9-B7B5-4329C82DCC1FQ36755004-DC015138-0ECE-41E9-97B5-94D6803C94FAQ37024770-41649D7F-0423-48F4-B4F3-765622F916F6Q37437368-EA6C0124-EC1C-45BF-A6BC-9700F1EE0532Q37439991-AE808D94-28C5-4F56-BF95-6E21EA03735DQ37466825-9FD59E6E-2DF4-4F43-9438-BA3CE90F9BABQ38204386-F692F284-13B3-4A66-8D51-B39A554AC479Q38246144-08673A92-D5C0-4D3E-B10C-E58B8C794CE6Q38694268-BE4AFBBA-DFF4-4A29-BE94-65451FFC16A8Q38703315-F13E6D27-9189-4A83-8C65-17F55B214DE2Q38725438-0CCD19BF-BBEC-405E-AB41-69D121AE375AQ38947405-3DE4FEA5-9736-40D0-952D-9DAED66069F2Q40779503-82BEA32C-7570-4DFA-AD1B-FCD9DD425D7BQ42706975-92A663FF-6676-44F1-907A-5D871AFF61FFQ47357144-64276D42-3E4C-4E1B-9891-71C9F4563F1FQ47687388-2BAC05E4-11E9-48AB-8FC1-A8EFA4E15D8CQ48237579-601CB574-AA4D-42D5-88AF-58EB1A50DD9BQ48599692-4AB26E75-BBFC-45D9-86AA-666777DCD71AQ55717745-61D9B979-768A-4E1A-B096-A9A38E04A8E5Q58746026-74BA9766-6C9C-44DC-852A-443FCFEEDFEA
P2860
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Histone deacetylase (HDAC) inh ...... t chemoresistant cancer cells.
@en
Histone deacetylase
@nl
type
label
Histone deacetylase (HDAC) inh ...... t chemoresistant cancer cells.
@en
Histone deacetylase
@nl
prefLabel
Histone deacetylase (HDAC) inh ...... t chemoresistant cancer cells.
@en
Histone deacetylase
@nl
P2093
P356
P1476
Histone deacetylase (HDAC) inh ...... st chemoresistant cancer cells
@en
P2093
Alexandra Hamacher
Holger Gohlke
Krystina Kuna
Linda Marek
Matthias U Kassack
Thomas Kurz
P304
P356
10.1021/JM301254Q
P407
P577
2013-01-08T00:00:00Z