Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.
about
Base excision repair and cancerAag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damageApurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1)Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.Mitochondria, energetics, epigenetics, and cellular responses to stress.Micro-irradiation tools to visualize base excision repair and single-strand break repairTumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts.Balancing repair and tolerance of DNA damage caused by alkylating agentsPoly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitisGenome instability caused by a germline mutation in the human DNA repair gene POLB.
P2860
Q27025537-DC968537-1184-4DB2-B25B-4CE297C3092BQ27323759-13472F37-65E1-4727-B8BD-D823FA6DE6E2Q33970153-6E2813B4-0A0C-444A-ABB0-59036942DA6FQ34438595-BDEFED8B-4D40-4283-8418-CD7C9DFCEDD7Q34474381-67C3CA4F-7ACA-4779-8F26-327F7B3E0680Q34635899-CA2FDDD2-AB94-4991-BB7D-FE1298556F7FQ35690306-2676681F-D044-4805-9011-FF61A8985D05Q36316513-811F9F43-CA9A-406A-9C86-07930C97EE2FQ36439915-83287AA6-88C0-41B5-B10C-34268CA4DD93Q36651488-1AE2F523-14E9-4E1C-A6BB-85896E5E0AF1Q36808573-4E9A5451-88D9-48E9-B820-B7EBDF684FB4Q41333908-15653CAE-9C28-4932-9A2B-21D4E60E790E
P2860
Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Parp1 activation in mouse embr ...... sitivity to alkylation damage.
@en
Parp1 activation in mouse embr ...... sitivity to alkylation damage.
@nl
type
label
Parp1 activation in mouse embr ...... sitivity to alkylation damage.
@en
Parp1 activation in mouse embr ...... sitivity to alkylation damage.
@nl
prefLabel
Parp1 activation in mouse embr ...... sitivity to alkylation damage.
@en
Parp1 activation in mouse embr ...... sitivity to alkylation damage.
@nl
P2093
P2860
P1433
P1476
Parp1 activation in mouse embr ...... sitivity to alkylation damage.
@en
P2093
Ashley R Brown
Elena Jelezcova
Eva M Goellner
Jamie L Fornsaglio
Jiang-Bo Tang
Ram N Trivedi
Robert W Sobol
Sandy Schamus
Xiao-Hong Wang
P2860
P356
10.1016/J.MRFMMM.2010.01.016
P407
P577
2010-01-22T00:00:00Z