Mutations that confer resistance to template-analog inhibitors of human immunodeficiency virus (HIV) type 1 reverse transcriptase lead to severe defects in HIV replication.
about
HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors.Inhibition of Hepatitis C Virus (HCV) RNA Polymerase by DNA Aptamers: Mechanism of Inhibition of In Vitro RNA Synthesis and Effect on HCV-Infected CellsRNA-protein interactions govern antiviral specificity and encapsidation of broad spectrum anti-HIV reverse transcriptase aptamersNovel aptamer inhibitors of human immunodeficiency virus reverse transcriptase.Inhibition of HIV-1 reverse transcriptase by RNA aptamers in Escherichia coli.Mutations proximal to the minor groove-binding track of human immunodeficiency virus type 1 reverse transcriptase differentially affect utilization of RNA versus DNA as template.Pharmacogenomic strategies against resistance development in microbial infections.Cross-clade inhibition of recombinant human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus SIVcpz reverse transcriptases by RNA pseudoknot aptamers.High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase.Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases.Therapeutic applications of aptamers.Finding aptamers and small ribozymes in unexpected places.Use of Capillary Electrophoresis to Study the Binding Interaction of Aptamers with Wild-Type, K103N, and Double Mutant (K103N/Y181C) HIV-1 RT : Studying the Binding Interaction of Wild-Type, K103N, and Double Mutant (K103N/Y181C) HIV-1 RT with AptamEvolution toward small molecule inhibitor resistance affects native enzyme function and stability, generating acarbose-insensitive cyclodextrin glucanotransferase variants.Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers.Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates.Endogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1.Potent inhibition of human immunodeficiency virus type 1 replication by template analog reverse transcriptase inhibitors derived by SELEX (systematic evolution of ligands by exponential enrichment).Aptamers: novel molecules as diagnostic markers in bacterial and viral infections?
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P2860
Mutations that confer resistance to template-analog inhibitors of human immunodeficiency virus (HIV) type 1 reverse transcriptase lead to severe defects in HIV replication.
description
2002 nî lūn-bûn
@nan
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
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2002年论文
@zh-cn
name
Mutations that confer resistan ...... re defects in HIV replication.
@en
Mutations that confer resistan ...... f human immunodeficiency virus
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type
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Mutations that confer resistan ...... re defects in HIV replication.
@en
Mutations that confer resistan ...... f human immunodeficiency virus
@nl
prefLabel
Mutations that confer resistan ...... re defects in HIV replication.
@en
Mutations that confer resistan ...... f human immunodeficiency virus
@nl
P2860
P1433
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Mutations that confer resistan ...... re defects in HIV replication.
@en
P2093
Pheroze Joshi
Timothy S Fisher
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10.1128/JVI.76.8.4068-4072.2002
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2002-04-01T00:00:00Z