Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.
about
DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansionUnpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleasesCrystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how flap endonuclease-1 family nucleases bind their substratesExpression and biochemical characterization of the Plasmodium falciparum DNA repair enzyme, flap endonuclease-1 (PfFEN-1)Molecular interactions of Escherichia coli ExoIX and identification of its associated 3'-5' exonuclease activity.Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ionsMechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease PRate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences.Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonucleaseFlap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.Roles of divalent metal ions in flap endonuclease-substrate interactions.Sequence-specific cleavage of RNA in the absence of divalent metal ions by a DNAzyme incorporating imidazolyl and amino functionalities.Nucleophile activation in PD...(D/E)xK metallonucleases: an experimental and computational pK(a) study.Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing.Active site substitutions delineate distinct classes of eubacterial flap endonuclease.Structure-function analysis of Trypanosoma brucei RNA triphosphatase and evidence for a two-metal mechanism.
P2860
Q24538026-EDD5C6C5-0EC7-4F8A-9B12-F7CEC1BC9C81Q27005670-6BA18AF2-467C-4165-9950-D9890F63ECAAQ27647139-F192E213-0396-4A3D-9CD3-07266A13D266Q27972548-C78D3278-C04A-499D-B7D6-53FB708DF549Q33287593-925604DC-25DC-41C2-8165-CF11FC976510Q35183008-81D44C48-14D1-4DE1-AA2E-0FCB5AC4971AQ35861007-4C4729CA-439E-463B-AD54-F2DCF93036B0Q35978312-61290E86-E4E5-4507-88EB-6005CD90EF67Q36011996-079EDB70-01FE-4C96-BD1C-E5D4186392C6Q36044859-113794FE-97FA-43E6-B1D9-477D550540F6Q38342596-071A7EF9-22EA-494C-8D8A-DC34C6D446F0Q40773184-EF8A4202-0C5F-4029-A984-269F40343B5FQ41968683-A7747B58-BF06-49A2-9768-196145C329DFQ42632884-E7B6FB52-3540-4E1E-A520-12B2E17F8BFEQ42873076-FC1F5B83-B993-448E-AB32-7CD1B0DC8452Q43169464-01809ECB-47EB-4812-A62C-9DC3674745D8Q44606578-FB1156B7-F50F-43E1-98AF-E371D016CD1A
P2860
Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.
@en
Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.
@nl
type
label
Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.
@en
Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.
@nl
prefLabel
Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.
@en
Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.
@nl
P2093
P2860
P356
P1433
P1476
Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease
@en
P2093
Elaine Frary
Jane A Grasby
Mark R Tock
P2860
P304
P356
10.1093/EMBOJ/CDG098
P407
P577
2003-03-01T00:00:00Z