A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
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The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradationA thrombospondin-dependent pathway for a protective ER stress responseRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinUbiquitin-Mediated Degradation of Aurora KinasesTRIM21: a cytosolic Fc receptor with broad antibody isotype specificityThe KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons for sexual receptivity in Drosophila femalesCdc48/p97 mediates UV-dependent turnover of RNA Pol II.The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteinsProtection of armadillo/β-Catenin by armless, a novel positive regulator of wingless signalingBasic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48.Defining the geometry of the two-component proteasome degronThe VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?Intrinsically disordered segments affect protein half-life in the cell and during evolution.Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.The complexities of p97 function in health and diseaseEvaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex.Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system.In silico and in vivo investigations of proteins of a minimized eukaryotic cytoplasm.Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.Disordered form of the scaffold protein IscU is the substrate for iron-sulfur cluster assembly on cysteine desulfuraseAAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα.Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs.Structure and function of the AAA+ ATPase p97/Cdc48p.Role of p97/VCP (Cdc48) in genome stability.Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.The role of bacterial enhancer binding proteins as specialized activators of σ54-dependent transcriptionIntracellular antibody immunity.Stalled proteasomes are directly relieved by P97 recruitment.Structural disorder and its role in proteasomal degradation.The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation.A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.Rapid proteasomal degradation of posttranscriptional regulators of the TIS11/tristetraprolin family is induced by an intrinsically unstructured region independently of ubiquitination.The direction of protein entry into the proteasome determines the variety of products and depends on the force needed to unfold its two termini.
P2860
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P2860
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
@en
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
@nl
type
label
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
@en
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
@nl
prefLabel
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
@en
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
@nl
P2093
P1476
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
@en
P2093
Anne Beskow
Florian A Salomons
Kristian Björk Grimberg
Laura C Bott
Patrick Young
P304
P356
10.1016/J.JMB.2009.09.050
P407
P577
2009-09-24T00:00:00Z