about
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaksAlzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formationMutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand BreaksThe polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex.VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFDShould I stay or should I go: VCP/p97-mediated chromatin extraction in the DNA damage responseA small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophyA dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodelingExpression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionFunctional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysisA new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.The ubiquitin/proteasome system in Epstein-Barr virus latency and associated malignancies.The chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.Monitoring the ubiquitin/proteasome system in conformational diseases.Fluorescent probes for proteolysis: tools for drug discovery.Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosisRecognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complexDDB2 promotes chromatin decondensation at UV-induced DNA damage.Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage.The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteinsHeterochromatin protein 1 is recruited to various types of DNA damage.Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation.Stressing the ubiquitin-proteasome system.Illuminating the ubiquitin/proteasome system.Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin.The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation.Spatiotemporal regulation of posttranslational modifications in the DNA damage response.Ubiquitin crosstalk connecting cellular processes.A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stressMinimal length requirement for proteasomal degradation of ubiquitin-dependent substrates.Disease-associated prion protein oligomers inhibit the 26S proteasome.Biogenesis and processing of the amyloid precursor protein in the early secretory pathway.COPI-mediated retrograde transport is required for efficient gamma-secretase cleavage of the amyloid precursor protein.Ubiquitin versus misfolding: The minimal requirements for inclusion body formation.
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P50
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hulumtues
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հետազոտող
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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Nico P. Dantuma
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P106
P1153
6604061652
P21
P31
P496
0000-0002-6090-4170