about
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevityRegulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processesThe small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice.Compound prioritization methods increase rates of chemical probe discovery in model organisms.The drug efflux-metabolism alliance: biochemical aspects.LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acidsMapping the cellular response to small molecules using chemogenomic fitness signatures.Liver X receptors regulate adrenal cholesterol balance.Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein.Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and LethalityLecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes.Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland.Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells.Identification and quantitation of sorbitol-based nuclear clarifying agents extracted from common laboratory and consumer plasticware made of polypropylene.Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues.Glucocorticoids and Metabolic Control.Subchronic glucocorticoids, glutathione depletion and a postpartum model elevate monoamine oxidase a activity in the prefrontal cortex of rats.The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells.Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).Liver X Receptors as Therapeutic Targets for Managing Cholesterol: Implications for Atherosclerosis and Other Inflammatory ConditionsSIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control.Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
P50
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P50
description
hulumtuese
@sq
researcher
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wetenschapper
@nl
հետազոտող
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name
Carolyn L Cummins
@nl
Carolyn L Cummins
@sl
Carolyn L. Cummins
@en
Carolyn L. Cummins
@es
type
label
Carolyn L Cummins
@nl
Carolyn L Cummins
@sl
Carolyn L. Cummins
@en
Carolyn L. Cummins
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altLabel
Carolyn Cummins
@en
prefLabel
Carolyn L Cummins
@nl
Carolyn L Cummins
@sl
Carolyn L. Cummins
@en
Carolyn L. Cummins
@es
P106
P1153
7102791416
P21
P31
P496
0000-0001-7603-6577