Mapping the cellular response to small molecules using chemogenomic fitness signatures.
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Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing?Mitochondrial targets for pharmacological intervention in human diseaseOpen Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos ArylpyrrolesMitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis.Large-scale chemical similarity networks for target profiling of compounds identified in cell-based chemical screensBiological data analysis as an information theory problem: multivariable dependence measures and the shadows algorithmHigh-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal ErgolinesChemogenomics and orthology-based design of antibiotic combination therapiesPhosphatidylinositol transfer proteins and instructive regulation of lipid kinase biologyExperimental and Computational Analysis of a Large Protein Network That Controls Fat Storage Reveals the Design Principles of a Signaling NetworkStructural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors.Sec14-like phosphatidylinositol-transfer proteins and diversification of phosphoinositide signalling outcomes.Systems cell biology.The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.Off-target effects of the septin drug forchlorfenuron on nonplant eukaryotesSelect microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.Protein homology reveals new targets for bioactive small molecules.Rapid quantification of mutant fitness in diverse bacteria by sequencing randomly bar-coded transposons.Identification of a Mitochondrial DNA Polymerase Affecting Cardiotoxicity of Sunitinib Using a Genome-Wide Screening on S. pombe Deletion Library.Beyond Agar: Gel Substrates with Improved Optical Clarity and Drug Efficiency and Reduced Autofluorescence for Microbial Growth Experiments.Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design.Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells.Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 PathwayIdentification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal PathogensThe effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiaeNetwork-assisted target identification for haploinsufficiency and homozygous profiling screens.Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress.High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance.A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial DysfunctionPredicting chemotherapeutic drug combinations through gene network profilingChemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting.Translation of Genotype to Phenotype by a Hierarchy of Cell SubsystemsSystematic identification and correction of annotation errors in the genetic interaction map of Saccharomyces cerevisiae.Utilizing yeast chemogenomic profiles for the prediction of pharmacogenomic associations in humans.Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesisTranscriptome and network analyses in Saccharomyces cerevisiae reveal that amphotericin B and lactoferrin synergy disrupt metal homeostasis and stress response.
P2860
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P2860
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
description
2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2014 թվականի ապրիլին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
@zh-mo
2014年論文
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2014年论文
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name
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@ast
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@en
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@nl
type
label
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@ast
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@en
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@nl
prefLabel
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@ast
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@en
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@nl
P2093
P2860
P50
P356
P1433
P1476
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
@en
P2093
Ana Maria Aparicio
Anna Y Lee
Anuradha Surendra
Chris A Kaiser
Corey Nislow
Elena Lissina
Eric D Spear
Geoffrey Duby
Guri Giaever
P2860
P304
P356
10.1126/SCIENCE.1250217
P407
P50
P577
2014-04-01T00:00:00Z