about
MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemiaLow doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesisHighly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels.Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.A unified nomenclature and amino acid numbering for human PTEN.The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways.Interleukin-7 in T-cell acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis?Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells.In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas.microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemiaIL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity.Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling.The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival.Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises.IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia.The multiple layers of non-genetic regulation of PTEN tumour suppressor activity.PTEN and leukemia stem cells.Kinases, tails and more: regulation of PTEN function by phosphorylation.CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics.CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress.From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia.AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors.Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells.IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to gammadelta T-cell cytotoxicity.Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability.Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors.Molecular and functional evidence for activity of murine IL-7 on human lymphocytes.Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity.IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.Checkmate to CHK1 in T-cell ALL?
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
João T Barata
@es
João T Barata
@nl
João T Barata
@sl
João T. Barata
@en
type
label
João T Barata
@es
João T Barata
@nl
João T Barata
@sl
João T. Barata
@en
altLabel
Joao T. Barata
@en
prefLabel
João T Barata
@es
João T Barata
@nl
João T Barata
@sl
João T. Barata
@en
P1053
D-9181-2015
P106
P1153
7006937224
P21
P31
P496
0000-0002-4826-8976