Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596.
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Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived NeuronsDesign, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperaturesChanges in temperature have opposing effects on current amplitude in α7 and α4β2 nicotinic acetylcholine receptors.A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats.Ion channel screening: advances in technologies and analysis.The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia.Activation of Phosphorylase Kinase by Physiological Temperature.The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels.Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents.The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface.Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states.Nicotinic acetylcholine receptors at the single-channel level.At-Line Cellular Screening Methodology for Bioactives in Mixtures Targeting the α7-Nicotinic Acetylcholine Receptor.The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.Automated Patch Clamp Analysis of nAChα7 and Na(V)1.7 Channels.Molecular function of α7 nicotinic receptors as drug targets.
P2860
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P2860
Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596.
description
2011 nî lūn-bûn
@nan
2011年の論文
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2011年学术文章
@wuu
2011年学术文章
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2011年学术文章
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2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
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2011年學術文章
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name
Voltage- and Temperature-Depen ...... otinic Receptors by PNU120596.
@en
Voltage- and Temperature-Depen ...... otinic Receptors by PNU120596.
@nl
type
label
Voltage- and Temperature-Depen ...... otinic Receptors by PNU120596.
@en
Voltage- and Temperature-Depen ...... otinic Receptors by PNU120596.
@nl
prefLabel
Voltage- and Temperature-Depen ...... otinic Receptors by PNU120596.
@en
Voltage- and Temperature-Depen ...... otinic Receptors by PNU120596.
@nl
P2093
P2860
P356
P1476
Voltage- and Temperature-Depen ...... otinic Receptors by PNU120596.
@en
P2093
Andrew D Randall
Fabrio Sitzia
John Dunlop
Jon T Brown
P2860
P356
10.3389/FPHAR.2011.00081
P577
2011-12-27T00:00:00Z