Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide) - Test2 - elhamkhani - TriplyDB

Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide)

Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide)

http://www.wikidata.org/entity/Q28302487

about

SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking in rats Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen Nicotinic ACh receptors as therapeutic targets in CNS disorders Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile Nicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disorders Effects of the nicotinic α7 receptor partial agonist GTS-21 on NMDA-glutamatergic receptor related deficits in sensorimotor gating and recognition memory in rats Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures In search of allosteric modulators of a7-nAChR by solvent density guided virtual screening.Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors.Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist.Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies.Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicoti Targeting brain α7 nicotinic acetylcholine receptors in Alzheimer's disease: rationale and current status.Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties.The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596.A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties.Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors.Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats.

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P2860

Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide)

http://www.wikidata.org/entity/Q28302487

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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Old and new pharmacology: posi ...... ]di pyrrole-1(2H)-carboxamide)

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Old and new pharmacology: posi ...... ]di pyrrole-1(2H)-carboxamide)

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Old and new pharmacology: posi ...... ]di pyrrole-1(2H)-carboxamide)

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Old and new pharmacology: posi ...... ]di pyrrole-1(2H)-carboxamide)

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Old and new pharmacology: posi ...... ]di pyrrole-1(2H)-carboxamide)

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JPET.108.146514

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Journal of Pharmacology and Experimental Therapeutics

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Old and new pharmacology: posi ...... ]di pyrrole-1(2H)-carboxamide)

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Adam Gilbert

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Angela Kramer

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