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Evaluating Human Embryonic Germ Cells: Concord and Conflict as Pluripotent Stem CellsIn vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human isletsCentriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetesStem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?Maturation of induced pluripotent stem cell derived hepatocytes by 3D-cultureLRIG2 mutations cause urofacial syndromeInactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial baseHuman β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetesBiocompatibility and osteogenic potential of human fetal femur-derived cells on surface selective laser sintered scaffolds.Steroidogenic factor 1 (SF-1) is essential for ovarian development and function.Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1Periderm prevents pathological epithelial adhesions during embryogenesis.The self-orientation of mammalian cells in optical tweezers--the importance of the nucleus.A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.The stress of starvation: glucocorticoid restraint of beta cell development.In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual developmentMicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.The window period of NEUROGENIN3 during human gestation.Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like SyndromeTEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.Tissue-specific knockouts of steroidogenic factor 1.Generation of Distal Airway Epithelium from Multipotent Human Foregut Stem Cells.Derivation of a novel undifferentiated human foetal phenotype in serum-free cultures with BMP-2.Human embryonic germ cells for future neuronal replacement therapy.Human embryo and early fetus research.Stem cell marker TRA-1-60 is expressed in foetal and adult kidney and upregulated in tubulo-interstitial disease.The human fetal adrenal cortex and the window of sexual differentiation.Insights into the molecular mechanism for type 2 diabetes susceptibility at the KCNQ1 locus from temporal changes in imprinting status in human islets.Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered proteaseOsteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans.Age-specific changes in sex steroid biosynthesis and sex development.Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells?Embryonic stem cells to beta-cells by understanding pancreas development.Development of the human pancreas from foregut to endocrine commitment.An integrative transcriptomic atlas of organogenesis in human embryos.The adrenal cortex and sexual differentiation during early human development.Generation of multipotent foregut stem cells from human pluripotent stem cells.The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.
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Neil A. Hanley
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Neil A. Hanley
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