Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.
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Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressThe F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stressATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage responseNAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b)Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7Induction of cullin 7 by DNA damage attenuates p53 functionDNA damage control: regulation and functions of checkpoint kinase 1Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BCheckpoint kinase 1 in DNA damage response and cell cycle regulationThe cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial designRoles of Chk1 in cell biology and cancer therapyHCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stabilityATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosisA phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer.Global regulation of genome duplication in eukaryotes: an overview from the epifluorescence microscope.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Ataxin-3 promotes genome integrity by stabilizing Chk1.Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling.PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.Turnover of BRCA1 involves in radiation-induced apoptosis.Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathwaysMechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damageStructure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damageProtein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpointChk1 requirement for high global rates of replication fork progression during normal vertebrate S phase.UbcH7 regulates 53BP1 stability and DSB repairLoss of autophagy causes a synthetic lethal deficiency in DNA repair.Comparative analysis of radiosensitizers for K-RAS mutant rectal cancersPhosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuitThe ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice.The fork and the kinase: a DNA replication tale from a CHK1 perspective.Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation.Phosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons.
P2860
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P2860
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.
@en
type
label
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.
@en
prefLabel
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.
@en
P2093
P1433
P1476
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway
@en
P2093
Diane M Otterness
Frank Mercurio
Robert T Abraham
Weilin Xie
You-Wei Zhang
P304
P356
10.1016/J.MOLCEL.2005.07.019
P577
2005-09-01T00:00:00Z