about
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phaseSIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1Arginine methylation regulates DNA polymerase betaEpstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation.HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activatorEnhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic fieldA macrodomain-containing histone rearranges chromatin upon sensing PARP1 activationCrosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during InflammationTranscription coactivator p300 binds PCNA and may have a role in DNA repair synthesisPoly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feedingA continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions.Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression.Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammationFine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling.PARP1 ADP-ribosylates lysine residues of the core histone tails.Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation.Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet.HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination.The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchangeSET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress.Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cellsRegulation of beta -catenin transformation by the p300 transcriptional coactivator.ARTD1 Suppresses Interleukin 6 Expression by Repressing MLL1-Dependent Histone H3 Trimethylation.The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturationImportin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLSThe diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.PKC signaling prevents irradiation-induced apoptosis of primary human fibroblastsARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells.PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation.Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue.Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage.Toward a unified nomenclature for mammalian ADP-ribosyltransferases.Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways.ARTD2 activity is stimulated by RNA.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Michael O Hottiger
@ast
Michael O Hottiger
@en
Michael O Hottiger
@es
Michael O Hottiger
@nl
Michael O Hottiger
@sl
type
label
Michael O Hottiger
@ast
Michael O Hottiger
@en
Michael O Hottiger
@es
Michael O Hottiger
@nl
Michael O Hottiger
@sl
altLabel
Michael Hottiger
@en
prefLabel
Michael O Hottiger
@ast
Michael O Hottiger
@en
Michael O Hottiger
@es
Michael O Hottiger
@nl
Michael O Hottiger
@sl
P1053
J-7747-2013
P106
P21
P2798
P31
P3829
P496
0000-0002-7323-2270