Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3.
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GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel BlockersThe chemical biology of clinically tolerated NMDA receptor antagonistsGlutamate receptor ion channels: structure, regulation, and functionMapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptorThe effect of noise on CaMKII activation in a dendritic spine during LTP inductionRecent insights into the mode of action of memantine and ketamineLocal constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening.Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulatorsSpecific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gatingEthanol inhibition of constitutively open N-methyl-D-aspartate receptors.Different sites of alcohol action in the NMDA receptor GluN2A and GluN2B subunits.Extracellular proton-modulated pore-blocking effect of the anticonvulsant felbamate on NMDA channelsMutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol actionInteractions among positions in the third and fourth membrane-associated domains at the intersubunit interface of the N-methyl-D-aspartate receptor forming sites of alcohol action.Probing the activation sequence of NMDA receptors with lurcher mutationsMolecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia.Subunit-specific contribution of pore-forming domains to NMDA receptor channel structure and gating.The Hydrophobic Effect Contributes to the Closed State of a Simplified Ion Channel through a Conserved Hydrophobic Patch at the Pore-Helix CrossingAll atom NMDA receptor transmembrane domain model development and simulations in lipid bilayers and water.Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors.An NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions.Intersubunit interactions at putative sites of ethanol action in the M3 and M4 domains of the NMDA receptor GluN1 and GluN2B subunits.A novel alcohol-sensitive position in the N-methyl-D-aspartate receptor GluN2A subunit M3 domain regulates agonist affinity and ion channel gating.Control of NMDA receptor function by the NR2 subunit amino-terminal domainMechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains.Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy.Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification.Mechanism of differential control of NMDA receptor activity by NR2 subunitsEvidence that Xenon does not produce open channel blockade of the NMDA receptor.Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block.Key binding interactions for memantine in the NMDA receptor.Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains.De Novo Variants in GRIA4 Lead to Intellectual Disability with or without Seizures and Gait Abnormalities.De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.NMDA Receptors in the Central Nervous System.Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate.An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.
P2860
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P2860
Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Conserved structural and funct ...... ng by transmembrane domain M3.
@en
type
label
Conserved structural and funct ...... ng by transmembrane domain M3.
@en
prefLabel
Conserved structural and funct ...... ng by transmembrane domain M3.
@en
P2093
P2860
P356
P1476
Conserved structural and funct ...... ng by transmembrane domain M3.
@en
P2093
Hongjie Yuan
Kevin Erreger
Shashank M Dravid
Stephen F Traynelis
P2860
P304
29708-29716
P356
10.1074/JBC.M414215200
P407
P577
2005-06-21T00:00:00Z