An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter
about
The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complexAR1 is an integral part of the adenovirus type 2 E1A-CR3 transactivation domain.Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae.Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation.Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation.The transcriptional co-activator proteins p300 and CBP stimulate adenovirus E1A conserved region 1 transactivation independent of a direct interaction.Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes.A novel E1A domain mediates skeletal-muscle-specific enhancer repression independently of pRB and p300 binding.The adenovirus e3 promoter is sensitive to activation signals in human T cells.Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter.Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.Inhibition of MITF transcriptional activity independent of targeting p300/CBP coactivators.Requirement of Sur2 for efficient replication of mouse adenovirus type 1.The DNA binding domains of the yeast Gal4 and human c-Jun transcription factors interact through the zinc-finger and bZIP motifs.E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products.Comparison of E1A CR3-dependent transcriptional activation across six different human adenovirus subgroups.Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivationTargeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.Mimicry of cellular A kinase anchoring proteins is a conserved and critical function of E1A across various human adenovirus species.
P2860
Q28275328-F9D188BC-026F-466F-8F70-65DD7F109D1FQ32061549-F30FA47C-A777-4B0C-8755-3AE6F540F79AQ33431467-137DBEF9-094C-4A3A-B006-8A789CB21E2CQ33902989-AD9CF0D1-1EF3-4215-AF27-83D01BCDB275Q34381615-1A54E3A4-A11E-42DD-A69C-47E541A35C46Q34601820-A5F72588-4135-4697-B72E-AD013991FC96Q34778486-7751148E-818C-4833-AFA2-0201D0274196Q36883871-C0A16185-C565-4D91-ABD5-6230AA8B66DBQ37127084-568B1DF6-4106-4E2F-9380-6444CDA38161Q38352779-DEA0E664-CE82-4A92-8F03-2029DC9C6E75Q38359241-BCCA896B-4453-4852-A4CA-6B8D3115E7F3Q39874705-25FC2695-F02B-47D0-9F53-42AF203481D2Q39897926-22DA1388-14C8-4B0C-8679-DD0CB9CC5132Q40179630-7531D680-3914-4875-ADCE-C085D2314F3EQ40275053-381907D7-E356-47C1-A0DB-BE0F0CDE4501Q40393050-CA302520-D0E4-4974-AE9B-F4850184472CQ40894288-ED20C47D-B2DE-4A25-B456-C529551CB5A0Q41232401-3D3E8C9E-F9AE-419A-87BB-910BD7DE688DQ42280948-1936E990-4456-4C58-B71E-28FAC5092139Q42676601-7BA0714D-D51B-42C5-87AB-4B215A237228Q47549172-5E2D6E43-A5FF-48F7-B37E-237A5CCBD34C
P2860
An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
An adenovirus E1A transcriptio ...... or when tethered to a promoter
@en
type
label
An adenovirus E1A transcriptio ...... or when tethered to a promoter
@en
prefLabel
An adenovirus E1A transcriptio ...... or when tethered to a promoter
@en
P2860
P356
P1476
An adenovirus E1A transcriptio ...... or when tethered to a promoter
@en
P2093
Akusjärvi G
Bondesson M
P2860
P304
P356
10.1093/NAR/22.15.3053
P577
1994-08-01T00:00:00Z