Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity
about
Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repairAn overview of Cdk1-controlled targets and processesDisruption of mechanisms that prevent rereplication triggers a DNA damage responseNej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism.The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiae.DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response.Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stressSaccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activitiesDNA helicase Srs2 disrupts the Rad51 presynaptic filamentThe DNA replication checkpoint response stabilizes stalled replication forksSrs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeastReplication protein A is sequentially phosphorylated during meiosis.Evidence of meiotic crossover control in Saccharomyces cerevisiae through Mec1-mediated phosphorylation of replication protein A.Effects of mutations in SGS1 and in genes functionally related to SGS1 on inverted repeat-stimulated spontaneous unequal sister-chromatid exchange in yeastThe CDK-activating kinase (CAK) Csk1 is required for normal levels of homologous recombination and resistance to DNA damage in fission yeast.Srs2: the "Odd-Job Man" in DNA repair.Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance.Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damageA single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway.Checkpoints: it takes more than time to heal some wounds.The DNA repair helicase UvrD is essential for replication fork reversal in replication mutantsIdentification of MCM4 as a target of the DNA replication block checkpoint system.A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability.Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae.Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication.A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombeThe short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombinationUV irradiation causes the loss of viable mitotic recombinants in Schizosaccharomyces pombe cells lacking the G(2)/M DNA damage checkpoint.Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functionsBiochemistry of eukaryotic homologous recombination.Suppression of spontaneous genome rearrangements in yeast DNA helicase mutantsSrs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles.Temporal separation of replication and recombination requires the intra-S checkpoint.Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage.Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNAS-phase checkpoint genes safeguard high-fidelity sister chromatid cohesionCdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae.
P2860
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P2860
Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-my
2000年学术文章
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2000年學術文章
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2000年學術文章
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name
Srs2 DNA helicase is involved ...... dent pathway and Cdk1 activity
@en
type
label
Srs2 DNA helicase is involved ...... dent pathway and Cdk1 activity
@en
prefLabel
Srs2 DNA helicase is involved ...... dent pathway and Cdk1 activity
@en
P2093
P2860
P356
P1433
P1476
Srs2 DNA helicase is involved ...... dent pathway and Cdk1 activity
@en
P2093
A Pellicioli
M Muzi-Falconi
P2860
P304
P356
10.1093/EMBOJ/19.18.5027
P407
P577
2000-09-01T00:00:00Z