Cross-linking of DNA induced by chloroethylnitrosourea is presented by O6-methylguanine-DNA methyltransferase
about
Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agentDepletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpAn analysis of the mutagenicity of 1,2-dibromoethane to Escherichia coli: influence of DNA repair activities and metabolic pathways.Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents.Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureasStudies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.The effects of pretreatment of human tumour cells with MNNG on the DNA crosslinking and cytotoxicity of mitozolomide.DNA interstrand cross-linking and cytotoxicity induced by chloroethylnitrosoureas and cisplatin in human glioma cell lines which vary in cellular concentration of O6-alkylguanine-DNA alkyltransferase.Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene.Phosphotriester adducts (PTEs): DNA's overlooked lesion.Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesisO6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.Purification of a HeLa cell nuclear protein that binds selectively to DNA irradiated with ultra-violet light.The 1987 Walter Hubert lecture. Regulation and deficiencies in DNA repair.DNA repair: relationship to drug and radiation resistance, metastasis and growth factors.Mutant Escherichia coli Ada proteins simultaneously defective in the repair of O6-methylguanine and in gene activation.Evidence that covalent complex formation between BCNU-treated oligonucleotides and E. coli alkyltransferases requires the O6-alkylguanine function.Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.Emergence of nitrosourea resistant sublines of Lewis lung tumour following MeCCNU treatment in vivo.Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.The chloroethylnitrosoureas: sensitivity and resistance to cancer chemotherapy at the molecular level.Activity of a new nitrosourea (TCNU) in human lung cancer xenografts.Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas.Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection.Claudin-7 indirectly regulates the integrin/FAK signaling pathway in human colon cancer tissue.
P2860
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P2860
Cross-linking of DNA induced by chloroethylnitrosourea is presented by O6-methylguanine-DNA methyltransferase
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年学术文章
@wuu
1983年学术文章
@zh-cn
1983年学术文章
@zh-hans
1983年学术文章
@zh-my
1983年学术文章
@zh-sg
1983年學術文章
@yue
1983年學術文章
@zh
1983年學術文章
@zh-hant
name
Cross-linking of DNA induced b ...... lguanine-DNA methyltransferase
@en
type
label
Cross-linking of DNA induced b ...... lguanine-DNA methyltransferase
@en
prefLabel
Cross-linking of DNA induced b ...... lguanine-DNA methyltransferase
@en
P2093
P2860
P356
P1476
Cross-linking of DNA induced b ...... lguanine-DNA methyltransferase
@en
P2093
P2860
P304
P356
10.1093/NAR/11.22.7743
P577
1983-11-01T00:00:00Z