Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site.
about
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulatorIdentification of a novel extracellular cation-sensing G-protein-coupled receptorPharmacology and physiology of gastrointestinal enteroendocrine cellsMembrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCRMolecular Basis of the Extracellular Ligands Mediated Signaling by the Calcium Sensing ReceptorGeneric GPCR residue numbers - aligning topology maps while minding the gapsPresynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminalsExploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinGPRC6A null mice exhibit osteopenia, feminization and metabolic syndromeAllosteric modulation of metabotropic glutamate receptors.The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors.Minireview: the intimate link between calcium sensing receptor trafficking and signaling: implications for disorders of calcium homeostasis.Mechanisms of multimodal sensing by extracellular Ca(2+)-sensing receptors: a domain-based survey of requirements for binding and signallingThe use of G-protein coupled receptor models in lead optimization.Calcium-sensing receptor biosynthesis includes a cotranslational conformational checkpoint and endoplasmic reticulum retentionNovel calcium sensing receptor ligands: a patent survey.Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis.Structural insights into human GPCR protein OA1: a computational perspective.Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer's DiseaseThe extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells.Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators.New concepts in calcium-sensing receptor pharmacology and signallingThe Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1).Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.Towards a structural understanding of allosteric drugs at the human calcium-sensing receptorAllosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders.Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors.Extracellular calcium as an integrator of tissue function.Allosteric Modulation of G Protein Coupled Receptors by Cytoplasmic, Transmembrane and Extracellular Ligands.Pharmacochaperone-mediated rescue of calcium-sensing receptor loss-of-function mutants.Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.Behind the curtain: cellular mechanisms for allosteric modulation of calcium-sensing receptors.The calcium sensing receptor: from calcium sensing to signaling.Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain.Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis.Allosteric modulation of the calcium-sensing receptor.Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation.Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.
P2860
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P2860
Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Homology modeling of the trans ...... of an allosteric binding site.
@en
type
label
Homology modeling of the trans ...... of an allosteric binding site.
@en
prefLabel
Homology modeling of the trans ...... of an allosteric binding site.
@en
P2093
P2860
P356
P1476
Homology modeling of the trans ...... of an allosteric binding site.
@en
P2093
Gerda E Breitwieser
Klaus Seuwen
Lucio Gama
Romain M Wolf
Susanne U Miedlich
P2860
P304
P356
10.1074/JBC.M307191200
P407
P577
2003-12-02T00:00:00Z