Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
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Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsThe Use of Multiscale Molecular Simulations in Understanding a Relationship between the Structure and Function of Biological Systems of the Brain: The Application to Monoamine Oxidase EnzymesG Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsExosomes: The Link between GPCR Activation and Metastatic Potential?Neurobiological Insights from mGlu Receptor Allosteric Modulation.Structural Studies of G Protein-Coupled ReceptorsPost-expression strategies for structural investigations of membrane proteins.Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatmentLarge-scale production and protein engineering of G protein-coupled receptors for structural studiesInvestigation of allosteric modulation mechanism of metabotropic glutamate receptor 1 by molecular dynamics simulations, free energy and weak interaction analysisStructure of class C GPCR metabotropic glutamate receptor 5 transmembrane domainMembrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR FunctionMolecular Basis of the Extracellular Ligands Mediated Signaling by the Calcium Sensing ReceptorNovel Allosteric Modulators of G Protein-coupled ReceptorsGeneric GPCR residue numbers - aligning topology maps while minding the gapsStructural insights into ligand recognition and selectivity for classes A, B, and C GPCRsConformational states of the full-length glucagon receptorStructure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional ImplicationsmGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in RatsSequence, structure and ligand binding evolution of rhodopsin-like G protein-coupled receptors: a crystal structure-based phylogenetic analysisTaste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domainsStructural mechanism of ligand activation in human calcium-sensing receptor.Improving homology modeling of G-protein coupled receptors through multiple-template derived conserved inter-residue interactions.The role of experimental and computational structural approaches in 7TM drug discovery.A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptorsLabel noise in subtype discrimination of class C G protein-coupled receptors: A systematic approach to the analysis of classification errors.Membrane cholesterol access into a G-protein-coupled receptor.Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.G protein-coupled receptors in cardiac biology: old and new receptorsWhy is dimerization essential for class-C GPCR function? New insights from mGluR1 crystal structure analysis.The recombinant expression systems for structure determination of eukaryotic membrane proteinsAmino acid derivatives as bitter taste receptor (T2R) blockers.Molecular mechanisms for sweet-suppressing effect of gymnemic acids.Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channelsOpportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Molecular Insights into Metabotropic Glutamate Receptor Allosteric ModulationRapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors.Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophreniaTwo classes of cholesterol binding sites for the β2AR revealed by thermostability and NMR.
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P2860
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
description
2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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name
Structure of a class C GPCR me ...... und to an allosteric modulator
@ast
Structure of a class C GPCR me ...... und to an allosteric modulator
@en
Structure of a class C GPCR me ...... und to an allosteric modulator
@en-gb
Structure of a class C GPCR me ...... und to an allosteric modulator
@nl
type
label
Structure of a class C GPCR me ...... und to an allosteric modulator
@ast
Structure of a class C GPCR me ...... und to an allosteric modulator
@en
Structure of a class C GPCR me ...... und to an allosteric modulator
@en-gb
Structure of a class C GPCR me ...... und to an allosteric modulator
@nl
altLabel
Structure of a Class C GPCR Me ...... und to an Allosteric Modulator
@en
prefLabel
Structure of a class C GPCR me ...... und to an allosteric modulator
@ast
Structure of a class C GPCR me ...... und to an allosteric modulator
@en
Structure of a class C GPCR me ...... und to an allosteric modulator
@en-gb
Structure of a class C GPCR me ...... und to an allosteric modulator
@nl
P2093
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Structure of a class C GPCR me ...... und to an allosteric modulator
@en
P2093
Chong Wang
Gye Won Han
Hyekyung P Cho
P2860
P3181
P356
10.1126/SCIENCE.1249489
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P50
P577
2014-04-04T00:00:00Z