The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

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http://www.wikidata.org/entity/Q40726065
Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancerProtein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defectA novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochoresMeasurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitorsTargeting protein prenylation for cancer therapyCombination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase.Inhibition of farnesyltransferase: a rational approach to treat cancer?Farnesyltransferase inhibitors and their potential role in therapy for myelodysplastic syndromes and acute myeloid leukaemia.Phase I-II study of the farnesyl transferase inhibitor tipifarnib plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in HER2/neu-negative inflammatory carcinoma and non-inflammatory estrogen receptor-positive breast carcinoma.Mechanisms of Chromosome Congression during Mitosis.Mitosis as an anti-cancer drug target.Protein lipid modifications--More than just a greasy ballast.
P2860

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

Item
http://www.wikidata.org/entity/Q40726065
description
2002 nî lūn-bûn
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2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
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2002年學術文章
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name
The farnesyltransferase inhibi ...... d Ras and p53 mutation status.
@en
type
label
The farnesyltransferase inhibi ...... d Ras and p53 mutation status.
@en
prefLabel
The farnesyltransferase inhibi ...... d Ras and p53 mutation status.
@en
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P6179
P698
P356
P1433
P1476
The farnesyltransferase inhibi ...... nd Ras and p53 mutation status
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P6179
P698