Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
about
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndromeKinesin-5: cross-bridging mechanism to targeted clinical therapySingle-walled carbon nanotube-induced mitotic disruptionSIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancerFunctional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interferenceSurvivin is required for a sustained spindle checkpoint arrest in response to lack of tensionComponents of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunctionFinding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chipsUBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exitPlk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM componentsThe chromokinesin Kid is required for maintenance of proper metaphase spindle size.Mechanistic analysis of the mitotic kinesin Eg5.Monastrol inhibition of the mitotic kinesin Eg5.EB1 targets to kinetochores with attached, polymerizing microtubulesLoop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanismsAllosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding siteInhibition of Kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axonsKinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindlePathway of ATP hydrolysis by monomeric kinesin Eg5A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogeneQuantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fateIndividual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitroReversine increases the plasticity of lineage-committed mammalian cellsThe small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpointThe KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAKHistone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts.Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targetsFinding the needle in the haystack: why high-throughput screening is good for your health.Chemical genomics: what will it take and who gets to play?A mini-review on Biginelli adducts with notable pharmacological propertiesHitting the brakes: targeting microtubule motors in cancerForce generation by kinesin and myosin cytoskeletal motor proteinsIdentification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells.Mitochondria localize to the cleavage furrow in mammalian cytokinesisThe Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies.
P2860
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P2860
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@ast
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@en
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@nl
type
label
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@ast
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@en
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@nl
prefLabel
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@ast
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@en
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@nl
P2093
P3181
P1433
P1476
Small molecule inhibitor of mi ...... ed in a phenotype-based screen
@en
P2093
S J Haggarty
S L Schreiber
T J Mitchison
T M Kapoor
P3181
P356
10.1126/SCIENCE.286.5441.971
P407
P577
1999-10-29T00:00:00Z