Identification of the phosphatidylserine binding site in the C2 domain that is important for PKC alpha activation and in vivo cell localization.
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Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2Pb 2+ as Modulator of Protein–Membrane InteractionsProtein kinase C: poised to signalThe ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells.C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound stateThe calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cellsThe exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain.Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domainPhosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity.Phosphatidylinositol-4,5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCαThe cPLA2 C2alpha domain in solution: structure and dynamics of its Ca2+-activated and cation-free statesVitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα.Ca2+ activation of the cPLA2 C2 domain: ordered binding of two Ca2+ ions with positive cooperativity.Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα.Configuration of PKCalpha-C2 domain bound to mixed SOPC/SOPS lipid monolayers.Classical protein kinases C are regulated by concerted interaction with lipids: the importance of phosphatidylinositol-4,5-bisphosphate.The recruitment of p47(phox) and Rac2G12V at the phagosome is transient and phosphatidylserine dependent.Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation studyThe origin of C1A-C2 interdomain interactions in protein kinase Calpha.The molecular basis of differential subcellular localization of C2 domains of protein kinase C-alpha and group IVa cytosolic phospholipase A2.A new phosphatidylinositol 4,5-bisphosphate-binding site located in the C2 domain of protein kinase Calpha.C2 domain of protein kinase C alpha: elucidation of the membrane docking surface by site-directed fluorescence and spin labelingPhosphatidylserine-Dependent Catalysis of Stalk and Pore Formation by Synaptobrevin JMR-TMD Peptide.Differential roles of phosphatidylserine, PtdIns(4,5)P2, and PtdIns(3,4,5)P3 in plasma membrane targeting of C2 domains. Molecular dynamics simulation, membrane binding, and cell translocation studies of the PKCalpha C2 domain.Role of the Ca2+/phosphatidylserine binding region of the C2 domain in the translocation of protein kinase Calpha to the plasma membrane.Altered brain lipid composition in cyclooxygenase-2 knockout mouse.
P2860
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P2860
Identification of the phosphatidylserine binding site in the C2 domain that is important for PKC alpha activation and in vivo cell localization.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Identification of the phosphat ...... and in vivo cell localization.
@en
type
label
Identification of the phosphat ...... and in vivo cell localization.
@en
prefLabel
Identification of the phosphat ...... and in vivo cell localization.
@en
P50
P356
P1433
P1476
Identification of the phosphat ...... and in vivo cell localization
@en
P2093
M J Lopez-Andreo
P304
13898-13905
P356
10.1021/BI011303O
P407
P577
2001-11-01T00:00:00Z