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Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathwayG protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cellsThe Importance of Thrombin in Cerebral Injury and DiseaseX-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognitionAgonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanismAlphaB-crystallin, a low-molecular-weight heat shock protein, acts as a regulator of platelet functionThrombin regulates chemokine induction during human retinal pigment epithelial cell/monocyte interactionDifferential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissuesProtease nexin-1: a cellular serpin down-regulated by thrombin in rat aortic smooth muscle cellsCloning and tissue expression of the tissue prothrombinase Fgl-2 in the Sprague-Dawley ratThrombin-receptor activation and thrombin-induced brain tolerancePertussis toxin-sensitive G-protein and protein kinase C activity are involved in normal synapse elimination in the neonatal rat muscle.Regulation of nestin expression by thrombin and cell density in cultures of bone mesenchymal stem cells and radial glial cells.Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration, phosphorylation of ERK and activation of ternary complex factor.Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway.An integrated mathematical model of thrombin-, histamine-and VEGF-mediated signalling in endothelial permeability.Protease activated receptors: theme and variations.Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?Disturbance of endothelial barrier function by bacterial toxins and atherogenic mediators: a role for Rho/Rho kinase.Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.The involvement of a novel mechanism distinct from the thrombin receptor in the vasocontraction induced by trypsinThe role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?Enhanced contractile response to thrombin in the pregnant rat myometriumProtease-activated receptor (PAR)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle.Protein kinases and Hebbian function.Cytoskeletal mechanisms regulating vascular endothelial barrier function in response to acute lung injuryAbruption-associated prematurity.Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton.The emerging role of the thrombin receptor (PAR-1) in melanoma metastasis--a possible therapeutic target.Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons.The interaction of thrombin with blood platelets.Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2.Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function.Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammation.Ezrin/radixin/moesin proteins differentially regulate endothelial hyperpermeability after thrombin.Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase.Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro.Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells.Molecular mechanisms of endothelial hyperpermeability: implications in inflammation.Thrombin down-regulates the TGF-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1.
P2860
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P2860
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Cellular consequences of thrombin-receptor activation.
@en
type
label
Cellular consequences of thrombin-receptor activation.
@en
prefLabel
Cellular consequences of thrombin-receptor activation.
@en
P2093
P2860
P356
P1433
P1476
Cellular consequences of thrombin-receptor activation.
@en
P2093
P2860
P304
P356
10.1042/BJ3130353
P407
P478
313 ( Pt 2)
P577
1996-01-01T00:00:00Z