Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235.

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Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235.

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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Retinoblastoma cells activate ...... I3K/mTOR inhibitor NVP-BEZ235.

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Retinoblastoma cells activate ...... I3K/mTOR inhibitor NVP-BEZ235.

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Retinoblastoma cells activate ...... I3K/mTOR inhibitor NVP-BEZ235.

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P1476

Retinoblastoma cells activate ...... I3K/mTOR inhibitor NVP-BEZ235.

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P2093

Aaron L Sarver

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Chencheng Xie

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Colleen L Forster

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Huarui Lu

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Matthew J Freeman

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Timothy C Hallstrom

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Xiaohong Wang

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice

miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

AKT/PKB signaling: navigating downstream

What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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38084-38098

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scholarly article

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10.18632/ONCOTARGET.16970

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English

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2017-04-08T00:00:00Z

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P698

28445155

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P921

retinoblastoma

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5503517

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