about
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef proteinThe alternatively spliced acid box region plays a key role in FGF receptor autoinhibitionAccurate quantitation of protein expression and site-specific phosphorylationNMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognitionSolution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonistsThe structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalphaA novel, specific interaction involving the Csk SH3 domain and its natural ligandCrystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptidesSolution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 CapsidA conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function MutationsGlobal structures of IgG isotypes expressing identical variable regionsBinding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free formsStructural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-CrkThe solution structure of Abl SH3, and its relationship to SH2 in the SH(32) constructThe solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domainsThe solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunitsSolution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virusInterferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactionsPeptide recognition by PTB and PDZ domainsEvidence for the cerebral uptake in vivo from two pools of glucose and the role of glucose-6-phosphatase in removing excess substrate from brainA peptide mimic blocks the cross-reaction of anti-DNA antibodies with glomerular antigensDesign of a Split Intein with Exceptional Protein Splicing ActivityIdentification of Hydrophobic Interfaces in Protein-Ligand Complexes by Selective Saturation Transfer NMR Spectroscopy.Abl kinase constructs expressed in bacteria: facilitation of structural and functional studies including segmental labeling by expressed protein ligationSolution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II.Novel mechanism of regulation of the non-receptor protein tyrosine kinase Csk: insights from NMR mapping studies and site-directed mutagenesis.Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain.Flexibility of interdomain contacts revealed by topological isomers of bivalent consolidated ligands to the dual Src homology domain SH(32) of abelson.Chemical ligation of folded recombinant proteins: segmental isotopic labeling of domains for NMR studiesDevelopment of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G.Enhanced affinities and specificities of consolidated ligands for the Src homology (SH) 3 and SH2 domains of Abelson protein-tyrosine kinase.Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteinsStructural and dynamical features of inteins and implications on protein splicing.Integrating NOE and RDC using sum-of-squares relaxation for protein structure determination.The corrected nucleotide sequences of the TaqI restriction and modification enzymes reveal a thirteen-codon overlap.A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins.A cell-penetrating helical peptide as a potential HIV-1 inhibitor.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
David Cowburn
@ast
David Cowburn
@en
David Cowburn
@es
David Cowburn
@nl
David Cowburn
@sl
type
label
David Cowburn
@ast
David Cowburn
@en
David Cowburn
@es
David Cowburn
@nl
David Cowburn
@sl
prefLabel
David Cowburn
@ast
David Cowburn
@en
David Cowburn
@es
David Cowburn
@nl
David Cowburn
@sl
P106
P1153
7006065148
P21
P31
P496
0000-0001-6770-7172