A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein
about
Down-regulation of CTLA-4 by HIV-1 Nef proteinComprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteomeIdentification of preferred protein interactions by phage-display of the human Src homology-3 proteome.SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerHuman immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activityStructural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)Deciphering the cross talk between hnRNP K and c-Src: the c-Src activation domain in hnRNP K is distinct from a second interaction siteBinding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway.Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complexInteraction between PAK and nck: a template for Nck targets and role of PAK autophosphorylationSH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55HIV Genome-Wide Protein Associations: a Review of 30 Years of ResearchHepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interactionThe SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins.Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner.The peroxisomal membrane protein Pex13p shows a novel mode of SH3 interaction.Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor NefSrc-dependent phosphorylation of ASAP1 regulates podosomes.Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity LigandsHighly homologous proteins exert opposite biological activities by using different interaction interfacesInteraction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitmentThe accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenonPartial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, HckSingle-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functionsStructure, dynamics, and Hck interaction of full-length HIV-1 Nef.Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri TipHIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia.An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques.Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.Regions of human immunodeficiency virus type 1 nef required for function in vivoRole of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaquesHIV-1 Nef protein: purification, crystallizations, and preliminary X-ray diffraction studies.Refined solution structure and backbone dynamics of HIV-1 Nef.
P2860
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P2860
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@ast
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@en
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@nl
type
label
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@ast
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@en
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@nl
prefLabel
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@ast
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@en
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@nl
P2093
P2860
P1433
P1476
A single amino acid in the SH3 ...... n binding to HIV-1 Nef protein
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1995.TB00183.X
P407
P577
1995-10-01T00:00:00Z