about
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory elementA tripartite transcription factor network regulates primordial germ cell specification in miceTranscriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL lociProtocol: precision engineering of plant gene loci by homologous recombination cloning in Escherichia coliProneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motifGata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic developmentGenome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genesRunx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liverConBind: motif-aware cross-species alignment for the identification of functional transcription factor binding sitesA novel mode of enhancer evolution: the Tal1 stem cell enhancer recruited a MIR element to specifically boost its activityGrowth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.Building an ENCODE-style data compendium on a shoestring.Reconstructing blood stem cell regulatory network models from single-cell molecular profilesProcessing, visualising and reconstructing network models from single-cell data.BTR: training asynchronous Boolean models using single-cell expression data.Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting.Real-time PCR mapping of DNaseI-hypersensitive sites using a novel ligation-mediated amplification technique.A new RNASeq-based reference transcriptome for sugar beet and its application in transcriptome-scale analysis of vernalization and gibberellin responses.Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate.Key regulators control distinct transcriptional programmes in blood progenitor and mast cells.Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specificationConcerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms.Constrained transcription factor spacing is prevalent and important for transcriptional control of mouse blood cellsThe endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling.MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndromeGenome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.Decoding the regulatory network of early blood development from single-cell gene expression measurements.CODEX: a next-generation sequencing experiment database for the haematopoietic and embryonic stem cell communities.The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.Integration of Elf-4 into stem/progenitor and erythroid regulatory networks through locus-wide chromatin studies coupled with in vivo functional validationLong-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate geneClonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium.Index sorting resolves heterogeneous murine hematopoietic stem cell populationsShared transcription factors contribute to distinct cell fatesRUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia.A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding siteThe epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Berthold Gottgens
@ast
Berthold Gottgens
@en
Berthold Gottgens
@es
Berthold Gottgens
@sl
type
label
Berthold Gottgens
@ast
Berthold Gottgens
@en
Berthold Gottgens
@es
Berthold Gottgens
@sl
prefLabel
Berthold Gottgens
@ast
Berthold Gottgens
@en
Berthold Gottgens
@es
Berthold Gottgens
@sl
P106
P1153
6701818487
P21
P2456
P31
P496
0000-0001-6302-5705