The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1
about
The selection and function of cell type-specific enhancersConBind: motif-aware cross-species alignment for the identification of functional transcription factor binding sitesA far downstream enhancer for murine Bcl11b controls its T-cell specific expressionA novel mode of enhancer evolution: the Tal1 stem cell enhancer recruited a MIR element to specifically boost its activityReal-time PCR mapping of DNaseI-hypersensitive sites using a novel ligation-mediated amplification technique.Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.jMOSAiCS: joint analysis of multiple ChIP-seq datasets.Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain.Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cellsTranscriptional control of endothelial cell development.Effect of transcription-factor concentrations on leukemic stem cells.Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability.Remote control of gene expression.Dispensability of mammalian DNASingle site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses.Transcriptional regulation of haematopoietic transcription factors.Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development.Concise review: Blood relatives: formation and regulation of hematopoietic stem cells by the basic helix-loop-helix transcription factors stem cell leukemia and lymphoblastic leukemia-derived sequence 1.The ets transcription factor Fli-1 in development, cancer and disease.Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sitesA previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients.Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.Hard-wired heterogeneity in blood stem cells revealed using a dynamic regulatory network modelGenomic Alterations of Non-Coding Regions Underlie Human Cancer: Lessons from T-ALL.Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturationTranscriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo.cis-Regulatory remodeling of the SCL locus during vertebrate evolution.Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expressionThe SCL +40 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins.The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development.
P2860
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P2860
The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1
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2004 nî lūn-bûn
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2004年学术文章
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name
The scl +18/19 stem cell enhan ...... ancer bound by Fli-1 and Elf-1
@ast
The scl +18/19 stem cell enhan ...... ancer bound by Fli-1 and Elf-1
@en
type
label
The scl +18/19 stem cell enhan ...... ancer bound by Fli-1 and Elf-1
@ast
The scl +18/19 stem cell enhan ...... ancer bound by Fli-1 and Elf-1
@en
prefLabel
The scl +18/19 stem cell enhan ...... ancer bound by Fli-1 and Elf-1
@ast
The scl +18/19 stem cell enhan ...... ancer bound by Fli-1 and Elf-1
@en
P2093
P2860
P50
P1476
The scl +18/19 stem cell enhan ...... ancer bound by Fli-1 and Elf-1
@en
P2093
Anthony R Green
C Glenn Begley
Ekaterini Kotsopoulou
Jonathan Frampton
Kathy Knezevic
Linda M Barton
Liz Delaney
Maria-Jose Sanchez
Sandie Piltz
Sarah Kinston
P2860
P304
P356
10.1128/MCB.24.5.1870-1883.2004
P407
P577
2004-03-01T00:00:00Z