Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.
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Human perforin employs different avenues to damage membranesCa2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.Dual chaperone role of the C-terminal propeptide in folding and oligomerization of the pore-forming toxin aerolysinA conformational switch in the Piccolo C2A domain regulated by alternative splicingSynaptotagmin I functions as a calcium regulator of release probabilityGranule-dependent killing of Toxoplasma gondii by CD8+ T cellsHedgehog signaling controls T cell killing at the immunological synapse.Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.Biological characterization of Chlamydia trachomatis plasticity zone MACPF domain family protein CT153.CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.The major CD8 T cell effector memory subset in the normal and Chlamydia trachomatis-infected human endocervix is low in perforinLiving in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIVPerforin-mediated target-cell death and immune homeostasis.Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic functionPerforin deficiency and susceptibility to cancer.Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.An acidic microenvironment increases NK cell killing of Cryptococcus neoformans and Cryptococcus gattii by enhancing perforin degranulation.Perforin activity at membranes leads to invaginations and vesicle formation.In vitro atrazine-exposure inhibits human natural killer cell lytic granule release.How to induce involuntary suicide: the need for dipeptidyl peptidase I.Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis.Perforin and lymphohistiocytic proliferative disorders.Natural Killer Cell Receptors and Cytotoxic Activity in Phosphomannomutase 2 Deficiency (PMM2-CDG)Addressing the mysteries of perforin function.Human NK cell lytic granules and regulation of their exocytosisThe functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene.The transcriptional control of the perforin locusRunx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs.Impact of Pegylated Interferon-alfa-2a on Perforin Level in Patients With Chronic Hepatitis B; Preliminary Study.Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.Inherited defects in lymphocyte cytotoxic activity.Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining.The biogenesis of lysosomes and lysosome-related organellesCysteine cathepsins as regulators of the cytotoxicity of NK and T cells.Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiencyHuman and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L.Hepatocytes can induce death of contacted cells via perforin-dependent mechanism.Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells.
P2860
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P2860
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Perforin is activated by a pro ...... hospholipid-binding C2 domain.
@en
type
label
Perforin is activated by a pro ...... hospholipid-binding C2 domain.
@en
prefLabel
Perforin is activated by a pro ...... hospholipid-binding C2 domain.
@en
P2093
P2860
P50
P356
P1433
P1476
Perforin is activated by a pro ...... phospholipid-binding C2 domain
@en
P2093
L K MacDougall
M D Waterfield
P2860
P304
P356
10.1093/EMBOJ/16.24.7287
P407
P577
1997-12-01T00:00:00Z