Hsp70 alters tau function and aggregation in an isoform specific manner
about
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)PINCH in the cellular stress response to tau-hyperphosphorylation.Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization.Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's diseasePotential synergy between tau aggregation inhibitors and tau chaperone modulators.Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy.Screening strategies to identify HSP70 modulators to treat Alzheimer's disease.Cellular factors modulating the mechanism of tau protein aggregation.Therapeutic approaches in Parkinson's disease and related disorders.Therapeutic Strategies for Restoring Tau Homeostasis.Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of TauopathyChaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.Tau and neuron aging.HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation.A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.Mapping interactions with the chaperone network reveals factors that protect against tau aggregationTau in Oligodendrocytes Takes Neurons in Sickness and in Health
P2860
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P2860
Hsp70 alters tau function and aggregation in an isoform specific manner
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Hsp70 alters tau function and aggregation in an isoform specific manner
@en
type
label
Hsp70 alters tau function and aggregation in an isoform specific manner
@en
prefLabel
Hsp70 alters tau function and aggregation in an isoform specific manner
@en
P2093
P2860
P356
P1433
P1476
Hsp70 alters tau function and aggregation in an isoform specific manner
@en
P2093
Benjamin Combs
Kellen Voss
Kristina R Patterson
Lester I Binder
T Chris Gamblin
P2860
P304
P356
10.1021/BI2018078
P407
P577
2012-01-23T00:00:00Z