The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel.
about
Crystallographic insights into sodium-channel modulation by the β4 subunitHippocampal AMPA receptor gating controlled by both TARP and cornichon proteinsGabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesisGabapentin for smoking cessationNew molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channelsPharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentinMolecular targets for antiepileptic drug developmentA study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal ratsMechanisms of the gabapentinoids and α 2 δ-1 calcium channel subunit in neuropathic painThe Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic PotentialStructure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channelsThrombospondins as key regulators of synaptogenesis in the central nervous systemGlutamatergic transmission in drug reward: implications for drug addictionThe neurobiology of antiepileptic drugsGabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cordGabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neuronesPregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activityBlock by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclaseGabapentin misuse, abuse and diversion: a systematic reviewCentral Mechanisms Mediating Thrombospondin-4-induced Pain States.Pregabalin modulation of neurotransmitter release is mediated by change in intrinsic activation/inactivation properties of ca(v)2.1 calcium channels.Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.Paroxysmal dystonia induced by exercise and acetazolamide.Syringomyelia in the Cavalier King Charles spaniel (CKCS) dog.3-substituted GABA analogs with central nervous system activity: a review.Oxycodone combinations for pain relief.Gabapentin acts within the locus coeruleus to alleviate neuropathic painGabapentin in the management of convulsive disorders.Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs.Regulation of high-voltage-activated Ca(2+) channel function, trafficking, and membrane stability by auxiliary subunits.α2δ-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse.The pharmacologic basis of antiepileptic drug action.Gabapentin enacarbil - clinical efficacy in restless legs syndromeUse of gabapentin in the treatment of neuropathic pain.Gabapentin vs. low-dose transdermal estradiol for treating post-menopausal women with moderate to very severe hot flushes.Gabapentin for hot flashes in prostate cancer.Pharmacokinetics of pregabalin in subjects with various degrees of renal function.Pregabalin: a new anxiolytic.Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans.Pains, gains, and midbrains.
P2860
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P2860
The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
The novel anticonvulsant drug, ...... subunit of a calcium channel.
@en
type
label
The novel anticonvulsant drug, ...... subunit of a calcium channel.
@en
prefLabel
The novel anticonvulsant drug, ...... subunit of a calcium channel.
@en
P2093
P2860
P356
P1476
The novel anticonvulsant drug, ...... subunit of a calcium channel.
@en
P2093
G N Woodruff
V U Dissanayake
P2860
P304
P356
10.1074/JBC.271.10.5768
P407
P577
1996-03-01T00:00:00Z