Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system
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An optogenetic toolbox designed for primatesNeuroanatomy goes viral!VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's DiseaseAn adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vectorRecombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood.Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primatesGene delivery with viral vectors for cerebrovascular diseases.A comprehensive thalamocortical projection map at the mesoscopic levelAn animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1αα-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration.Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model tAdeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdalaThe production of viral vectors designed to express large and difficult to express transgenes within neurons.Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein.Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particlesRecombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation.Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus MacaquesImpact of age and vector construct on striatal and nigral transgene expression.Viral vector-mediated gene transfer for CNS disease.Heparin-binding correlates with increased efficiency of AAV1- and AAV6-mediated transduction of striated muscle, but negatively impacts CNS transductionGene therapy: a viable therapeutic strategy for Parkinson's disease?Research advances in gene therapy approaches for the treatment of amyotrophic lateral sclerosis.A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting.Spinal cord injury and the neuron-intrinsic regeneration-associated gene program.How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Gene regulation and genetics in neurochemistry, past to future.Application of viral vectors to the study of neural connectivities and neural circuits in the marmoset brainAAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models.Comparative analysis of the transduction efficiency of five adeno associated virus serotypes and VSV-G pseudotype lentiviral vector in lung cancer cellsLong, intrinsic horizontal axons radiating through and beyond rat barrel cortex have spatial distributions similar to horizontal spreads of activity evoked by whisker stimulation.Animal models of α-synucleinopathy for Parkinson disease drug development.Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices.Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNSEvaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex.Involvement of ventral tegmental area ionotropic glutamate receptors in the expression of ethanol-induced conditioned place preference.Herpes simplex virus type 1/adeno-associated virus hybrid vectors.Ectopic expression of TrKA in the adult rat basal ganglia induces both nerve growth factor-dependent and -independent neuronal responses.A comparative study of transfection efficiency between liposomes, immunoliposomes and brain-specific immunoliposomes.Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9.Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection.
P2860
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P2860
Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Comparison of transduction eff ...... n the rat nigrostriatal system
@en
type
label
Comparison of transduction eff ...... n the rat nigrostriatal system
@en
prefLabel
Comparison of transduction eff ...... n the rat nigrostriatal system
@en
P2093
P2860
P1476
Comparison of transduction eff ...... n the rat nigrostriatal system
@en
P2093
Jeng-Shin Lee
Nikolaus R McFarland
Pamela J McLean
P2860
P304
P356
10.1111/J.1471-4159.2009.06010.X
P407
P577
2009-02-24T00:00:00Z