Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.
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Synthesis of nucleoside phosphate and phosphonate prodrugsTargeting SH2 domains in breast cancerActivities of masked 2',3'-dideoxynucleoside monophosphate derivatives against human immunodeficiency virus in resting macrophagesAn in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugsAnti-HIV pronucleotides: SATE versus phenyl as a protecting group of AZT phosphoramidate derivativesSynthesis of dual function (5R,6R)- and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agentsAZT-5'-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agentImportance of the alanine methyl ester side chain for the biological activity profile of dual-function phenyl phosphate derivatives of bromo-methoxy-zidovudinePhosphoramidate derivatives of stavudine as inhibitors of HIV: unnatural amino acids may substitute for alanine.Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds.Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides.[d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase.Antiviral therapy for human immunodeficiency virus infectionsSynthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.Advances in brain targeting and drug delivery of anti-HIV therapeutic agents.Bis-ketol nucleoside triesters as prodrugs of the antiviral nucleoside triphosphate analogues of 3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine.Pro-nucleotide inhibitors of adenylyl cyclases in intact cells.Synthesis and evaluation of some masked phosphate esters of the anti-herpesvirus drug 882C (netivudine) as potential antiviral agents.Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency.Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).Synthesis and biological evaluation of substituted phosphate triester alkyl lyso phospholipids (ALPs) as novel potential anti-neoplastic agents.Certain phosphoramidate derivatives of dideoxy uridine (ddU) are active against HIV and successfully by-pass thymidine kinase.Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV ReplicationAnchimerically Activatable Antiviral ProTides.Synthesis and anti-herpetic activity of phosphoramidate ProTides.Synthesis of phosphoramidate prodrugs: ProTide approach.Pharmacokinetics of bis(t-butyl-SATE)-AZTMP, a bispivaloylthioethyl prodrug for intracellular delivery of zidovudine monophosphate, in mice.Influence of a Calpha-substitution on the S-pivaloyl-2-thioethyl chain on the anti-HIV activity and stability of the resulting zidovudine mononucleoside phosphotriester.Synthesis and anti-HIV activity of carbamates of antiviral agent stavudine.Symmetrical diamidate prodrugs of nucleotide analogues for drug delivery.AZT and AZT-monophosphate prodrugs incorporating HIV-protease substrate fragment: synthesis and evaluation as specific drug delivery systems.A novel synthesis of antiviral nucleoside phosphoramidate and thiophosphoramidate prodrugs via nucleoside H-phosphonamidates.Synthesis and Evaluation of Biological Activity of New Arylphosphoramidates
P2860
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P2860
Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.
@en
type
label
Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.
@en
prefLabel
Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.
@en
P2093
P356
P1476
Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.
@en
P2093
Balzarini J
De Clercq E
McGuigan C
Pathirana RN
P304
P356
10.1021/JM00060A013
P407
P577
1993-04-01T00:00:00Z