Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology.
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Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatumPathology and pathophysiology of the amygdala in epileptogenesis and epilepsyα-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced NeuropathologyTargeting G protein coupled receptor-related pathways as emerging molecular therapiesA review of experimental evidence linking neurotoxic organophosphorus compounds and inflammationEfficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changesCharacterization of status epilepticus induced by two organophosphates in rats.Treatment of drug-induced seizuresSpatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxicationAnimal models that best reproduce the clinical manifestations of human intoxication with organophosphorus compoundsModels to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents(-)-Phenserine attenuates soman-induced neuropathologyLY293558 prevents soman-induced pathophysiological alterations in the basolateral amygdala and the development of anxiety.The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.The recovery of acetylcholinesterase activity and the progression of neuropathological and pathophysiological alterations in the rat basolateral amygdala after soman-induced status epilepticus: relation to anxiety-like behavior.Somatostatin type-2 receptor activation inhibits glutamate release and prevents status epilepticusCentral cholinesterase inhibition enhances glutamatergic synaptic transmission.Mass spectrometry identifies multiple organophosphorylated sites on tubulin.Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents.Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate.Using MRI for the assessment of paraoxon-induced brain damage and efficacy of antidotal treatment.The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations.Higher susceptibility of the ventral versus the dorsal hippocampus and the posteroventral versus anterodorsal amygdala to soman-induced neuropathology.Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are blocked by a GluR5 kainate receptor antagonist in vitroPathophysiological mechanisms underlying increased anxiety after soman exposure: reduced GABAergic inhibition in the basolateral amygdala.Soman increases neuronal COX-2 levels: possible link between seizures and protracted neuronal damage.Effects of fosphenytoin on nerve agent-induced status epilepticus.The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology.The piriform cortex and human focal epilepsy.Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injuryEffective countermeasure against poisoning by organophosphorus insecticides and nerve agentsTranscriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin.Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures.Neuroprotective efficacy of caramiphen against soman and mechanisms of its action.Midazolam as an anticonvulsant antidote for organophosphate intoxication--A pharmacotherapeutic appraisalA rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonistsExploring adduct formation between human serum albumin and eleven organophosphate ester flame retardants and plasticizers using MALDI-TOF/TOF and LC-Q/TOFEfficacy of the GluK1/AMPA receptor antagonist LY293558 against seizures and neuropathology in a soman-exposure model without pretreatment and its pharmacokinetics after intramuscular administrationAdvances in toxicology and medical treatment of chemical warfare nerve agentsOverexpression of μ-calpain in the anterior temporal neocortex of patients with intractable epilepsy correlates with clinicopathological characteristics
P2860
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P2860
Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology.
@en
type
label
Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology.
@en
prefLabel
Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology.
@en
P1476
Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology.
@en
P2093
McDonough JH Jr
P304
P356
10.1016/S0149-7634(96)00050-4
P577
1997-09-01T00:00:00Z